AI Article Synopsis
- Magnetic-responsive materials, particularly superparamagnetic nanoparticles, are gaining attention in biomedical applications like bone tissue engineering due to their biocompatibility and stability.
- Researchers developed a composite scaffold using chitosan/collagen mixed with nano-hydroxyapatite and FeO nanoparticles for enhanced mechanical properties and cell compatibility.
- In tests with SD rats, this magnetic scaffold demonstrated improved bone regeneration and tissue compatibility compared to a control group, highlighting its potential for treating bone defects.
Article Abstract
Magnetic-responsive materials are promising for applications in various biomedical fields. Especially, superparamagnetic nanoparticles are widely used in magnetic system for bone tissue engineering owing to superior biocompatibility and long term stability. Based on the idea of in situ bionics, we successfully incorporate the nano-hydroxyapatite (nHAP) and FeO nanoparticles which were prepared by in situ crystallization and freeze-drying technique into the chitosan/collagen (CS/Col) organic matrix to achieve the uniform dispersion of inorganic substrate with nanometer-scale. The in vitro results of the physicochemical and biocompatibility tests showed that CS/Col/FeO/nHAP magnetic scaffold possessed superior structural and mechanical performance for cell adhesion and proliferation, as well as the osteogenic differentiation. Mineralization experiments showed better bioactive and good ability of in situ biomimetic mineralization. Moreover, from the in vivo model of SD rats' skull defects proved that the CS/Col/FeO/nHAP hybrid scaffold had a better tissue compatibility and higher bone regeneration ability when implanted into the skull defects comparing to control group. Herein, the magnetic hybrid micro/nanostructured scaffold showed a potential application for bone defect repair.
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| http://dx.doi.org/10.1016/j.colsurfb.2018.11.003 | DOI Listing |
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