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The extrathymic T-cell differentiation in the murine gut.
Immunol Rev
February 2007
Institut National de la Santé et de la Recherche Médicale (INSERM), U591, Faculté de Médecine René Descarte Paris V, Institut Necker, Paris, France.
The gut epithelial border is in continuous contact with exogenous antigens and harbors a distinctive and very abundant CD8 alpha alpha intraepithelial T-lymphocyte effector population. We describe here the characteristics of these cells that distinguish them from all other T-cell types in the body as well as their functions in local protection. We also describe how these cells differentiate from local precursors present in the gut cryptopatches (CPs) following a pathway of T-cell differentiation unique to the gut wall.
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