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Hydrogen Bonding-Driven Adaptive Coacervates as Protocells.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Coacervation based on liquid-liquid phase separation (LLPS) has been widely used for the preparation of artificial protocells and to mimic the dynamic organization of membrane-free organelles. Most complex synthetic coacervates are formed through electrostatic interactions but cannot withstand high ionic strength conditions (>0.1 M).
View Article and Find Full Text PDFStand Diversity Does Not Mitigate Increased Herbivory on Climate-Matched Oaks in an Assisted Migration Experiment.
Plant Cell Environ
January 2025
Department of Biological Sciences, Royal Holloway University of London, Egham, UK.
Assisted migration is a tree-planting method where tree species or populations are translocated with the aim of establishing more climate-resilient forests. However, this might potentially increase the susceptibility of translocated trees to herbivory. Stand diversification through planting trees in species or genotypic mixtures may reduce the amount of damage by insect pests, but its effectiveness in mitigation of excess herbivory on climate-matched trees has seldom been explored.
View Article and Find Full Text PDFBiocompatible autonomous self-healing PVA-CS/TA hydrogels based on hydrogen bonding and electrostatic interaction.
Sci Rep
January 2025
State Key Laboratory of Structure Analysis, Optimization and CAE Software for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, 116024, China.
The biocompatible autonomous self-healing hydrogels have great potential in biomedical applications. However, the fairly weak tensile strength of the hydrogels seriously hinders their application. Here, we introduced chitosan (CS) into the polyvinyl alcohol (PVA)-tannic acid (TA) hydrogel and investigated the effects of the CS content, as CS can not only form reversible H bonds with PVA and TA but also form reversible electrostatic interactions with TA.
View Article and Find Full Text PDFSpatiotemporal Dynamic Immunomodulation by Infection-Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses.
Adv Sci (Weinh)
January 2025
SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Despite their safety and widespread use, conventional protein antigen-based subunit vaccines face significant challenges such as low immunogenicity, insufficient long-term immunity, poor CD8 T-cell activation, and poor adaptation to viral variants. To address these issues, an infection-mimicking gel (IM-Gel) is developed that is designed to emulate the spatiotemporal dynamics of immune stimulation in acute viral infections through in situ supramolecular self-assembly of nanoparticulate-TLR7/8a (NP-TLR7/8a) and an antigen with tannic acid (TA). Through collagen-binding properties of TA, the IM-Gel enables sustained delivery and enhanced retention of NP-TLR7/8a and protein antigen in the lymph node subcapsular sinus of mice for over 7 days, prolonging the exposure of vaccine components in both B cell and T cell zones, leading to robust humoral and cellular responses.
View Article and Find Full Text PDFSynergistic effect of proanthocyanidins and cefquinoxime sulfate on methicillin-resistant Staphylococcus aureus.
Pak J Pharm Sci
January 2025
Innovation Center Laboratory for Traditional Chinese Veterinary Medicine (TCVM), College of Veterinary Medicine, China Agricultural University, Beijing, China.
To address the severe problem of methicillin-resistant Staphylococcus aureus (MRSA) resistance, this study identified a single component from traditional Chinese medicine that, when used in combination with existing antibiotics, enhances the therapeutic efficacy of the antimicrobial drugs. Using the micro broth dilution method and the checkerboard dilution method, susceptibility tests were conducted on ten commonly used β-lactam antibiotics against eleven strains of MRSA. It was found that cefquinome sulfate exhibits synergistic activity with PROs.
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