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NMDA-induced lesions of the nucleus accumbens core increase the innately rewarding saccharin solution intake and methamphetamine-induced conditioned place preference but not conditioned taste aversion in rats.
Pharmacol Biochem Behav
January 2025
Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan. Electronic address:
The role of the nucleus accumbens (NAc) core in determining the valence of innately rewarding saccharin solution intake, methamphetamine (MAMPH)-induced conditioned taste aversion (CTA), and conditioned place preference (CPP) reward remains unclear. The present study utilized the "pre- and post-association" experimental paradigm (2010) to test whether the rewarding and aversive properties of MAMPH can be modulated by an N-methyl-D-aspartic acid (NMDA) lesion in the NAc core. Moreover, it tested how an NAc core NMDA lesion affected the innate reward of saccharin solution intake.
View Article and Find Full Text PDFAn integrative analysis reveals cancer risk associated with artificial sweeteners.
J Transl Med
January 2025
Medical College of YiChun University, Xuefu Road No 576, Yichun, 336000, Jiangxi, People's Republic of China.
Background: Artificial sweeteners (AS) have been widely utilized in the food, beverage, and pharmaceutical industries for decades. While numerous publications have suggested a potential link between AS and diseases, particularly cancer, controversy still surrounds this issue. This study aims to investigate the association between AS consumption and cancer risk.
View Article and Find Full Text PDFThermocontrolled Radical Nucleophilicity vs Radicophilicity in Regiodivergent C-H Functionalization.
Org Lett
January 2025
School of Chemical Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute, PO Bhimpur-Padanpur, Via Jatni, District Khurda, Odisha 752050, India.
The temperature-dependent switching behavior of the saccharin radical is demonstrated, enabling the regiodivergent C-H and C-H functionalization of quinoxalin-2(1)-ones. The saccharin radical was generated through N-Br bond cleavage in -bromosaccharin (NBSA) and was observed to transition between radical and radicophile roles. At -10 °C, it was utilized as a radicophile, resulting in 100% C-amination, while at +35 °C, it acted as a radical, leading to exclusive C-bromination.
View Article and Find Full Text PDFPeerPub: A Device for Concurrent Operant Oral Self-Administration by Multiple Rats.
eNeuro
January 2025
Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee 38163
The social environment has long been recognized to play an important role in substance use, which is often modeled in rodents using operant conditioning. However, most operant chambers only accommodate one rodent at a time. We present PeerPub-a unique social operant chamber.
View Article and Find Full Text PDFPrenatal Alcohol Exposure and Transient Systemic Hypoxia-Ischemia Result in Subtle Alterations in Dendritic Complexity in Medial Frontal Cortical Neurons in Juvenile and Young Adult Rat Offspring in a Pilot Study.
Cells
November 2024
Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Prenatal alcohol exposure (PAE) is associated with long-term neurodevelopmental deficits resulting in impaired executive functioning and motor control. Intriguingly, PAE has been linked with an increased risk of transient systemic hypoxia-ischemia (TSHI), which alone results in suboptimal fetal growth and neurodevelopmental consequences. Here, using two translationally relevant preclinical models, we investigated the short-term and lasting effects of PAE and TSHI on the morphology of the medial prefrontal cortex (mPFC), a region important in executive function, and tested whether PAE interacts with TSHI to produce a distinct pattern of injury relative to either condition alone.
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