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Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most prevalent type of senile dementia affecting more than 6 million Americans in 2023. Most of these AD cases are sporadic or late-onset AD with unclear etiology. Recent clinical trials on antibody drug clearing Ab plagues in brain show modest benefits of slowing down cognitive decline.
View Article and Find Full Text PDFFauna of Simuliids (Diptera: Simuliidae) of the Tormes River Hydrographic Basin in Central-Western Spain and their responses to abiotic factors in their habitats.
Acta Trop
December 2024
Laboratori d'Entomologia i Control de Plagues, Institut Universitari Cavanilles de Biodiversitat i Biologia Evolutiva (ICBiBE), Universitat de València (Estudi General), C/Catedrático José Beltrán 2, 46980, Paterna, València, España. Electronic address:
Delving into knowing the blackfly (Diptera: Simuliidae) species composition of Spain and their ecological requirements is crucial, due to their instrumental role in natural food webs as intermediaries in the flow of energy in aquatic ecosystems, and because of the haematophagic behaviour displayed by females of several species. The present study has analysed the abundance and distribution of the larvae and pupae of blackfly species in 105 sampling stations located in lotic water bodies of the provinces of Ávila, Salamanca, and Zamora of the Tormes River basin. The study has allowed to identify 24 species: 17 from Ávila, 13 from Salamanca, and seven from Zamora, classified in three genera (Metacnephia, Prosimulium, and Simulium), and five subgenera (Boophthora, Eusimulium, Nevermannia, Simulium, Wilhelmia).
View Article and Find Full Text PDFTwo live attenuated vaccines (LAVs), LMA and LMP, were evaluated alone or in combination with a trivalent adenoviral vector-based vaccine (Ad5-YFV) for their efficacy and immune responses in wild type (WT) and interferon gamma (IFNγ) knockout (KO) mice in a C57BL/6 background. While LMA and LMP are triple deletion mutants of CO92 strain, Ad5-YFV incorporates three protective plague immunogens. An impressive 80-100% protection was observed in all vaccinated animals against highly lethal intranasal challenge doses of parental CO92.
View Article and Find Full Text PDFAn epidemiological modeling investigation of the long-term changing dynamics of the plague epidemics in Hong Kong.
Math Biosci Eng
October 2024
Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong SAR, China.
Article Synopsis
- This study uses dynamic modeling to analyze the transmission of pneumonic plague in Hong Kong from 1902 to 1904, focusing on how human, flea, and rodent populations interact.
- By examining historical data and developing epidemic metrics like reproduction numbers, the research reveals key factors driving outbreaks, such as flea lifespan and rodent populations.
- The findings suggest that effective public health strategies should focus on controlling flea and rodent vectors to help prevent future outbreaks and improve overall disease management.
Identification and subcellular localization of proteins that interact with Duck plague virus pUL14 in infected host cells.
Poult Sci
December 2024
Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, PR China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, PR China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, PR China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China.
Duck plague (DP), which is caused by duck plague virus (DPV), is an infectious disease that severely harms the waterfowl breeding industry. The UL14 protein (pUL14) is a tegument protein encoded by the UL14 gene, which is located in the unique long (UL) region of the DPV genome. DPV pUL14 plays a crucial role in viral replication, likely by interacting with host and viral proteins that have yet to be identified.
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