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Drug-Drug Interaction Between Rifampicin and Albuvirtide: A Phase 1, Randomized, Open-Label Study.
J Clin Pharmacol
January 2025
Department of Pharmacy, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Albuvirtide (ABT) is a novel long-acting fusion inhibitor for human immunodeficiency virus type 1 (HIV-1), and may be co-administered with rifampicin (RIF) in patients concurrent with tubercle bacillus and HIV-1. This study was conducted to investigate the pharmacokinetic effect of co-administration of the two drugs. In the study, 24 healthy volunteers were randomized to receive ABT alone or with RIF.
View Article and Find Full Text PDFIsolated Tibial Tubercle Fracture With and Without Combined Patellar Tendon Avulsion: Early Outcomes, Complications, and Reoperations.
J Pediatr Orthop
January 2025
Departments of Orthopaedic Surgery.
Background: Tibial tubercle fractures (TTF) are uncommon injuries, comprising <3% of proximal tibial fractures. Rarely, they occur in conjunction with patellar tendon avulsion (PTA). We aimed to compare reoperation rates and short-term postoperative outcomes in patients with TTF versus combined injuries.
View Article and Find Full Text PDFHeterogeneity in the use of osseous risk factors and limited use of relevant patient-reported outcome measurements in studies investigating treatment of patellar dislocation: A scoping review.
Knee Surg Sports Traumatol Arthrosc
January 2025
Sports Orthopedic Research Center-Copenhagen (SORC-C), Department of Orthopedic Surgery, Copenhagen University Hospital, Amager-Hvidovre, Denmark.
Purpose: The treatment of patellar dislocation is tailored based on the presence or absence of osseous risk factors. The purpose of this scoping review was to investigate whether existing research addresses patient differences by mapping the use of osseous risk factors and patient-reported outcome measures (PROMs) in studies investigating the treatment of patellar dislocation.
Methods: This study was a scoping review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for Scoping Reviews.
The Study Aims: To evaluate and compare the growth of gingiva around dental implants following the use of collagen matrices and connective tissue grafts (CTG).
Materials And Methods: The study included 80 study participants, who were divided into four groups based on the type of material used to enhance gingival thickness. Two groups utilized collagen matrices, Fibro-Gide and FibroMatrix as materials, while the other two groups utilized CTG obtained from the hard palate or tubercle area of the maxilla as controls.
"Does advanced imaging improve the reliability of 2018 AO/OTA classification for trochanteric femoral fractures?".
J Orthop Sci
January 2025
Department of Orthopaedic Surgery, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, 110002, India. Electronic address:
Background: The influence of advanced imaging modalities on the reliability of 2018 AO/OTA classification and detection of features contributing to fracture instability have not been adequately studied in the literature.
Methods: This prospective study was conducted to assess the reliability of 2018 AO/OTA classification for trochanteric femoral fractures, and features of instability in 50 patients using radiographs, multiplanar reformats (MPR), and 3D-reconstruction with fracture segmentation (3DR-FS) by 3 observers on 2 occasions at an interval of 4 weeks.
Results: Mean inter-observer reliabilities on radiographs, MPR, 3DR-FS were 0.
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