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Portable paper-based microfluidic devices based on CuS@AgS nanocomposites for colorimetric/electrochemical dual-mode detection of dopamine.
Biosens Bioelectron
January 2025
Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory of UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, 130024, Changchun, China. Electronic address:
The development of integrated multiple signal outputs within a single platform is highly significant for efficient and accurate on-site biomarker detection. Herein, colorimetric/electrochemical dual-mode microfluidic paper-based analytical devices (μPADs) were designed for portable, visual and accurate dopamine (DA) detection. The dual-mode μPADs, featuring folded structure, integrate a colorimetric layer and an electrochemical layer using wax printing and laser-induced graphene (LIG) pyrolysis techniques, allowing the vertical flow of analyte solution.
View Article and Find Full Text PDFThe Significance of a Cerebrovascular Accident Outcome Prediction Model for Patients, Family Members, and Health Care Professionals: Qualitative Evaluation Study.
JMIR Hum Factors
January 2025
Department of Value Improvement, St. Antonius Hospital, Nieuwegein, Netherlands.
Background: Patients with cerebrovascular accident (CVA) should be involved in setting their rehabilitation goals. A personalized prediction of CVA outcomes would allow care professionals to better inform patients and informal caregivers. Several accurate prediction models have been created, but acceptance and proper implementation of the models are prerequisites for model adoption.
View Article and Find Full Text PDFCatalytic Asymmetric Dehydrogenative Si-H/X-H Coupling toward Si-Stereogenic Silanes.
Acc Chem Res
January 2025
Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
ConspectusChiral organosilicon compounds bearing a Si-stereogenic center have attracted increasing attention in various scientific communities and appear to be a topic of high current relevance in modern organic chemistry, given their versatile utility as chiral building blocks, chiral reagents, chiral auxiliaries, and chiral catalysts. Historically, access to these non-natural Si-stereogenic silanes mainly relies on resolution, whereas their asymmetric synthetic methods dramatically lagged compared to their carbon counterparts. Over the past two decades, transition-metal-catalyzed desymmetrization of prochiral organosilanes has emerged as an effective tool for the synthesis of enantioenriched Si-stereogenic silanes.
View Article and Find Full Text PDFAttitudes of German General Practitioners Toward eHealth Apps for Dementia Risk Reduction: Qualitative Interview Study.
JMIR Form Res
January 2025
Institute of Social Medicine, Occupational Health and Public Health, Leipzig University, Leipzig, Germany.
Background: eHealth interventions constitute a promising approach to disease prevention, particularly because of their ability to facilitate lifestyle changes. Although a rather recent development, eHealth interventions might be able to promote brain health and reduce dementia risk in older adults.
Objective: This study aimed to explore the perspective of general practitioners (GPs) on the potentials and barriers of eHealth interventions for brain health.
Large Language Models in Diabetes Management: The Need for Human and Artificial Intelligence Collaboration.
Diabetes Care
February 2025
Center for the Study of Aging and Human Development, Duke University, Durham, NC.
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