AI Article Synopsis
- Quinoline derivatives are being studied for their potential as new anticancer drugs due to their various biological activities.
- A range of substituted quinoline derivatives was tested for their effectiveness against various cancer cell lines, with two compounds, 6-Bromo-5-nitroquinoline and 6,8-diphenylquinoline, showing the most promise.
- Although 6-Bromo-5-nitroquinoline demonstrated less cytotoxicity than the established drug 5-fluorouracil, its ability to induce apoptosis suggests it could be a candidate for further research in cancer treatment.
Article Abstract
Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.
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| http://dx.doi.org/10.1002/jbt.22260 | DOI Listing |
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