AI Article Synopsis
- Glycosyl chlorides typically require harsh conditions and toxic promoters for activation, which can be a drawback in chemical processes.
- Recent research by the Ye and Jacobsen groups demonstrated the possibility of activating these compounds under milder organocatalytic conditions, but challenges like slow reactions and moderate yields persisted.
- This study presents a more straightforward method using inexpensive ferric chloride (FeCl3) as a catalyst, showing promising preliminary results in activating various glycosyl chlorides effectively.
Article Abstract
Glycosyl chlorides have historically been activated using harsh conditions and/or toxic stoichiometric promoters. More recently, the Ye and the Jacobsen groups showed that glycosyl chlorides can be activated under organocatalytic conditions. However, those reactions are slow, require specialized catalysts and high temperatures, but still provide only moderate yields. Presented herein is a simple method for the activation of glycosyl chlorides using abundant and inexpensive ferric chloride in catalytic amounts. Our preliminary results indicate that both benzylated and benzoylated glycosyl chlorides can be activated with 20 mol% of FeCl3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541213 | PMC |
| http://dx.doi.org/10.1039/c8ob02413h | DOI Listing |
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