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Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation.
BMC Cancer
January 2025
Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Background: Hematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary sequential treatments become increasingly frail and deconditioned.
View Article and Find Full Text PDFIntramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation.
Int J Obes (Lond)
January 2025
Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada.
Objective: Compared to adulthood-onset obesity (AO), those with childhood-onset obesity (CO) are at greater risk of metabolic disease. However, the differences between these two obesity phenotypes are not clear. The aim of this study is to investigate how the age of obesity onset (CO vs.
View Article and Find Full Text PDFAdverse childhood experiences, sleep quality/duration and later-life lower extremity function among older adults in China: evidence from CHARLS.
BMC Psychol
January 2025
College of Physical Education, Shandong Normal University, Jinan, 250358, China.
Objective: This study aimed to explore the relationship between adverse childhood experiences (ACEs), sleep, and lower extremity function in older adults using a nationally representative cohort.
Methods: This study included 4,439 participants aged 60 years or older (mean age: 67.2 ± 5.
Comparative evaluation of four exome enrichment solutions in 2024: Agilent, Roche, Vazyme and Nanodigmbio.
BMC Genomics
January 2025
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova str. 1, Moscow, 117997, Russia.
Whole exome sequencing (WES) is essential for identifying genetic variants linked to diseases. This study compares available to date four exome enrichment kits: Agilent SureSelect Human All Exon v8, Roche KAPA HyperExome, Vazyme VAHTS Target Capture Core Exome Panel, and Nanodigmbio NEXome Plus Panel v1. We evaluated target design, coverage statistics, and variant calling accuracy across these four different exome capture products.
View Article and Find Full Text PDFBackground And Aims: This article explores antibiotic resistance as a critical public health issue in Bangladesh, emphasizing its growing threat to the nation's healthcare system. As a developing country, Bangladesh faces unique challenges in managing this crisis, with antibiotic resistance posing significant risks due to its multidimensional problems to both individual health and the broader population.
Methods: We searched for relevant pieces of literature that discuss the antibiotic resistance problem both from a global and national perspective.
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