Mierzwa studies mechanisms of cell division in different cell types and tissue contexts.
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http://dx.doi.org/10.1083/jcb.201811004 | DOI Listing |
Mol Biol Cell
August 2024
Department of Biology, University of Vermont, Burlington VT 05405.
Astrobiology
August 2020
MRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom.
Biology experiments in space seek to increase our understanding of what happens to life beyond Earth and how we can safely send life beyond Earth. Spaceflight is associated with many (mal)adaptations in physiology, including decline in musculoskeletal, cardiovascular, vestibular, and immune systems. Biological experiments in space are inherently challenging to implement.
View Article and Find Full Text PDFJ Vis Commun Med
April 2020
Ludwig Institute for Cancer Research, San Diego; Department of Cellular and Molecular Medicine, University of California, San Diego, USA.
Nat Cell Biol
July 2017
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), AT-1030 Vienna, Austria.
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form persistent filaments that over time increase their curvature to constrict membranes. Unexpectedly, we found that ESCRT-III at the midbody of human cells rapidly turns over subunits with cytoplasmic pools while gradually forming larger assemblies.
View Article and Find Full Text PDFCorrect orientation of the mitotic spindle determines the plane of cellular cleavage and is crucial for organ development. In the developing cerebral cortex, spindle orientation defects result in severe neurodevelopmental disorders, but the precise mechanisms that control this important event are not fully understood. Here, we use a combination of high-content screening and mouse genetics to identify the miR-34/449 family as key regulators of mitotic spindle orientation in the developing cerebral cortex.
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