The flower heads of Inula britannica L. of Bulgarian origin afforded sesquiterpene lactones (gaillardin, britannin, I1, 13-dihydroinuchinenolide B, ivalin, pulchellin C), triterpenoids (3-0-palmitates of 160-hydroxylupeol, 16β-hydroxy-β-amyrin, and faradiol) and flavonoids (quercetin, luteolin, luteolin-7-0- glucoside). All compounds are known and they were identified by spectral methods. The observed differences in the chemical content of the chloroform and methanol extracts were also reflected in their free radical scavenging activity, evaluated by DPPH and ABTS assays. Intraspecific variability of L britannica is discussed.
Download full-text PDF |
Source |
---|
Molecules
December 2024
Department of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, Poland.
The genus has been used in folk medicine for centuries; however, the data concerning L. are scarce. This study aimed at investigating the chemical composition of methanolic and ethanolic extracts from the aerial parts of collected in Kazakhstan and evaluating their antimicrobial and antioxidant properties, with special attention being paid to polyphenols.
View Article and Find Full Text PDFPhytochemistry
March 2025
School of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China. Electronic address:
The immune system serves as a role of diseases, such as Parkinson's disease, and acute lung injury. An immunoregulatory activity-directed separation depended on phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Ion)-mediated Jurkat leukemic T cells was used for studying chemical constituents from Inula britannica L. in depth.
View Article and Find Full Text PDFChin Herb Med
October 2024
Faculity of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Objective: is a traditional Chinese medicinal and functional food with various effects such as anti-liver injury, hypoglycemia, antioxidants, and anti-tumor. The aim of this study was to investigate the protective effects and mechanisms of the ethanolic extract of (EEIB) on alcohol-induced liver injury in mice.
Methods: Fifty-six female C57BL/6 mice were randomly divided into seven groups: control group (Con), ethanol feeding model group (EtOH), Silibinin positive treatment group (EtOH + Silibinin 100 mg/kg), EEIB treatment group (EtOH + EEIB 100, 200, and 400 mg/kg), and EEIB control group (EEIB 400 mg/kg).
Antioxidants (Basel)
July 2024
Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
HT074, a multiherbal mixture containing extracts from flowers and roots, is used in Korean medicine for gastric disorders. This study investigated the protective mechanisms of HT074 against acute reflux esophagitis (RE) in rats. Nitric oxide (NO) production and mRNA expression of antioxidant-related genes (, , , , and ) were evaluated in LPS-induced RAW 264.
View Article and Find Full Text PDFPharmaceuticals (Basel)
April 2024
Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Str. Bl. 26, 1113 Sofia, Bulgaria.
The formation of microbial biofilm is a self-organizing process among bacterial cells, regulated by quorum-sensing (QS) mechanisms, contributing to development of infections. These processes, either separately or in combination, significantly contribute to bacterial resistance to antibiotics and disinfectants. A novel approach to addressing the challenge of treating infections due to antibacterial resistance involves the use of plant metabolites.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!