AI Article Synopsis
- A study was conducted on 4,122 preterm infants born at less than 35 weeks gestation to understand how prenatal complications, perinatal characteristics, neonatal morbidities, and socio-economic conditions impact various developmental disorders over the first 7 years of life.
- The researchers assessed developmental outcomes—including motor, sensory, cognitive, language, and psychological disorders—at regular intervals and analyzed factors such as birth weight, gestational age, and socio-economic status using statistical models.
- Results showed that perinatal characteristics had the greatest impact on developmental disorders, accounting for around 60% of the risk, while neonatal complications and socio-economic conditions varied in their contributions to specific disorders, with prenatal complications being the
Article Abstract
Background: To investigate the relative contributions of prenatal complications, perinatal characteristics, neonatal morbidities and socio-economic conditions on the occurrence of motor, sensory, cognitive, language and psychological disorders in a large longitudinal preterm infant population during the first 7 years after birth.
Methods: The study population comprised 4122 infants born at <35 weeks of gestation who were followed for an average of 74.0 months after birth. Developmental disorders, including motor, sensory, cognitive, language and psychological, were assessed at each follow-up visit from 18 months to 7 years of age. The investigated determinants included prenatal complications (prolonged rupture of membranes >24 hours, intrauterine growth restriction, preterm labour and maternal hypertension), perinatal characteristics (gender, multiple pregnancies, gestational age, birth weight, APGAR score and intubation or ventilation in the delivery room), neonatal complications (low weight gain during hospitalization, respiratory assistance, severe neurological anomalies, nosocomial infections) and socio-economic characteristics (socio-economic level, parental separation, urbanicity). Based on hazard ratios determined using a propensity score matching approach, population-attributable fractions (PAF) were calculated for each of the four types of determinants and for each developmental disorder.
Results: The percentages of motor, sensory, cognitive, language and psychological disorders were 17.0, 13.4, 29.1, 25.9 and 26.1%, respectively. The PAF for the perinatal characteristics were the highest and they were similar for the different developmental disorders considered (around 60%). For the neonatal and socio-economic determinants, the PAF varied according to the disorder, with contributions of up to 17% for motor and 27% for language disorders, respectively. Finally, prenatal complications had the lowest contributions (between 6 and 13%).
Conclusions: This study illustrates the heterogeneity of risk factors on the risk of developmental disorder in preterm infants. These results suggest the importance of considering both medical and psycho-social follow-ups of preterm infants and their families.
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| http://dx.doi.org/10.1093/ije/dyy240 | DOI Listing |
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