AI Article Synopsis
- Four new sesquiterpenoids, named Nardochinins A-D (1-4), were discovered in the roots of Nardostachys chinensis Batal and their structures were analyzed using spectroscopic methods and X-ray diffraction.
- Nardochinin A features a unique tetracyclic ring system not previously identified in natural products, while Nardochinins B and C are the first natural examples of sesquiterpenoids with a specific 4,5-seco-nardosinane skeleton.
- Nardochinin D introduces a highly oxygenated valerenane-type structure with rare epoxy groups, and among the compounds tested for anti-Alzheimer's activity, nardochinin B showed the strongest
Article Abstract
Nardochinins A-D (1-4), four novel sesquiterpenoids, along with four known ones were isolated from the underground parts of Nardostachys chinensis Batal in ethanol. Their structures were determined by extensive spectroscopic methods and single-crystal X-ray diffraction. Nardochinin A (1) possessed a norsesquiterpene skeleton with an unusual 3/6/5/5 tetracyclic ring system, which had not appeared in natural products. Nardochinins B (2) and C (3) were the first time found naturally occurring sesquiterpenoids with a 4,5-seco-nardosinane skeleton. Besides, compound 3 represented an unprecedented 4,5-seco-nardosinane type norsesquiterpenoid with losing an isopropenyl at C-6 compared with 2 in the structural framework. Nardochinin D (4) was a novel, highly oxygenated valerenane-type sesquiterpenoid possessing a rare 3,12-epoxy group and an unusual 9,11-epoxy group. The anti-Alzheimer's disease (AD) activities of 1-4 were also evaluated using the Caenorhabditis elegans AD pathological model, and nardochinin B (2) had the highest anti-AD activity.
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