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Geographical location of ischemic stroke patients affects thrombolysis availability in Denmark.

J Neurol Sci

January 2025

Pre-Hospital Center, Region Zealand, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Introduction: Early recognition and treatment of stroke is paramount for good outcome. Transport distance may result in delayed arrival for revascularization therapy. We investigated how transport time and distance to the revascularization unit affected the probability of receiving intravenous thrombolysis in Denmark between 2015 and 2020, for patients calling the Emergency Medical Services within three hours of symptom onset.

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Background: Despite decades of educational efforts, patients with acute ischemic stroke (AIS) remain delayed in seeking medical care, which becomes the greatest obstacle to the successful management of the condition.

Objective: To systematically explore the incidence and influencing factors of pre-hospital care-seeking delay in acute ischemic stroke patients.

Methods: We systematically searched the PubMed, Embase, Cochrane Library, Web of Science, and Cumulative Index to Nursing and Allied Health Literature from database inception to September 30, 2023.

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Objectives: Underutilisation of thrombolysis is a major problem in patients with stroke in Bangladesh as patients do not arrive within the therapeutic window due to delays in their way to emergency department. This study aims to assess the time delay from patients' symptom onset to arrival in the hospital and the factors that are associated with it.

Methods: This cross-sectional survey of a prospective cohort of stroke patients was conducted between January and March 2023.

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Article Synopsis
  • - The study analyzed 94 patients with acute ischemic stroke to determine how serum inflammatory factors, specifically IL-6 and TNF-α, impact prognosis after revascularization therapy.
  • - Patients were divided into good (mRS ≤ 2) and poor (mRS > 2) prognosis groups, with those in the good prognosis group showing lower levels of inflammatory markers and better clinical scores at admission.
  • - The findings suggest IL-6 and TNF-α could be useful indicators for predicting recovery outcomes in stroke patients post-treatment, indicating that those with higher levels may have worse prognoses.
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Objectives: To explore a novel model of mobile stroke units (MSUs) integrated with rural emergency medical stations for pre-hospital care of stroke patients in remote areas.

Methods: We used MSUs + Ambulance mode, where both the MSUs and conventional ambulances are sent to the patient's location. The conventional ambulance coordinates with the MSUs to choose the fastest route to meet and transfer the patient at the point along the way.

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