In this paper, we present a new FTIR-based microfluidic system for Glucose, Fructose and Sucrose detection. The proposed microfluidic system is based on a pseudo-continuous flow coupled to a microscope-FTIR instrument. The detection and characterization of sugar samples were performed by recording their absorption spectrum in the wavelength range 700⁻1000 cm - 1 of the Mid-IR region. The proposed pseudo-continuous flow system is designed to improve the uniformity of the sample distribution in the analyzed area versus conventional systems. The obtained results for different sugars concentrations, show a very low measurement error of 4.35% in the absorption peak intensity, which is ten times lower than the error obtained using the conventional measurements.
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http://dx.doi.org/10.3390/mi9100517 | DOI Listing |
J Cereb Blood Flow Metab
February 2025
Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark.
Psilocin, the active metabolite of psilocybin, is a psychedelic and agonist at the serotonin 2A receptor (5-HT2AR) that has shown positive therapeutic effects for brain disorders such as depression. To elucidate the brain effects of psilocybin, we directly compared the acute effects of 5-HT2AR agonist (psilocybin) and antagonist (ketanserin) on cerebral blood flow (CBF) using pseudo-continuous arterial spin labeling magnetic resonance imaging (MRI) in a single-blind, cross-over study in 28 healthy participants. We evaluated associations between plasma psilocin level (PPL) or subjective drug intensity (SDI) and CBF.
View Article and Find Full Text PDFFluids Barriers CNS
February 2025
Department of Radiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212001, China.
Background: Aβ deposition in the brain does not necessarily lead to cognitive impairment, and that blood supply may have other unexplained regulatory effects on Aβ. Therefore, there appears to be a more complex relationship between blood supply, Aβ deposition, and cognitive impairment that warrants further exploration.
Methods: This cohort study collected four longitudinal follow-up datasets, including a total of 281 subjects, followed for four years.
Neuroimage
April 2025
School of Computing, State University of New York at Binghamton, Binghamton, NY 13902, USA. Electronic address:
Normal aging has been associated with increased arterial transit time (ATT) and reduced cerebral blood flow (CBF). However, age-related patterns of ATT and CBF and their relationship remain unclear. This is partly due to the lengthy scan times required for ATT measurements, which caused previous age-related CBF studies to not fully account for transit time.
View Article and Find Full Text PDFRadiologia (Engl Ed)
February 2025
Grupo de Espectroscopia e Imágenes Cuantitativas por RM, Centro de Investigación de Imágenes Celulares y Moleculares, Universidad de Ciencias Médicas de Teherán, Teheran, Iran.
Background: Cerebral small vessel ischemic disease (SVID) as a common age-related morbidity is the key mechanism of vascular cognitive impairment (VCI). This study uses Cerebral blood flow (CBF) measured by pseudo-continuous ASL MRI in SVID patients with and without cognitive impairment to differentiate VCI from normal aging.
Materials And Methods: In this cross-sectional study, 74 SVID patients, including 35 with diagnosed VCI and 39 without cognitive impairment (control) underwent pCASL-MRI in the resting state.
J Magn Reson Imaging
February 2025
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Perfusion imaging of the brain has important clinical applications in detecting neurological abnormalities in neonates. However, such tools have not been available to date. Although arterial-spin-labeling (ASL) MRI is a powerful noninvasive tool to measure perfusion, its application in neonates has encountered obstacles related to low signal-to-noise ratio (SNR), large-vessel contaminations, and lack of technical development studies.
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