We investigated tip-enhanced Raman spectra excited by high-order fiber vector beams. Theoretical analysis shows that the high-order fiber vector beams have stronger longitudinal electric field components than linearly polarized light under tight focusing conditions. By introducing the high-order fiber vector beams and the linearly polarized beam from a fiber vector beam generator based on an electrically-controlled acoustically-induced fiber grating into a top-illumination tip-enhanced Raman spectroscopy (TERS) setup, the tip-enhanced Raman signal produced by the high-order fiber vector beams was 1.6 times as strong as that produced by the linearly polarized light. This result suggests a new type of efficient excitation light beams for TERS.
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http://dx.doi.org/10.3390/s18113841 | DOI Listing |
Int J Mol Sci
December 2024
Department of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Viral vector delivery of gene therapy represents a promising approach for the treatment of numerous retinal diseases. Adeno-associated viral vectors (AAV) constitute the primary gene delivery platform; however, their limited cargo capacity restricts the delivery of several clinically relevant retinal genes. In this study, we explore the feasibility of employing high-capacity adenoviral vectors (HC-AdVs) as alternative delivery vehicles, which, with a capacity of up to 36 kb, can potentially accommodate all known retinal gene coding sequences.
View Article and Find Full Text PDFClin Neurol Neurosurg
January 2025
Department of Neurosurgery, Hospital Clínic de Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Objective: to study the anatomical feasibility of laser fiber insertion for interstitial thermal therapy via transorbital approach to the temporo-mesial structures (amygdala-hippocampus-parahippocampus complex).
Methods: Anatomical dissections were performed bilaterally on two human cadaveric heads via a transorbital approach, in which screws and laser fibers were used for magnetic resonance imaging-guided laser interstitial thermal therapy (MRIgLITT) assisted by neuronavigation. In addition, eight transorbital trajectories were simulated using the transorbital entry points obtained from a cadaveric radiological study of four patients previously operated on for mesial temporal lobe epilepsy.
J Cachexia Sarcopenia Muscle
February 2025
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Background: Adeno-associated virus (AAV) 8 and 9 are in clinical trials for treating neuromuscular diseases such as Duchenne muscular dystrophy (DMD). Muscle consists of myofibres of different types and sizes. However, little is known about the fibre type and fibre size tropism of AAV in large mammals.
View Article and Find Full Text PDFMicromachines (Basel)
November 2024
Advanced Fiber Devices and Systems Group, Key Laboratory of Micro and Nano Photonic Structures (MoE), Key Laboratory for Information Science of Electromagnetic Waves (MoE), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, School of Information Science and Technology, Fudan University, Shanghai 200433, China.
Vector bending sensors can be utilized to detect the bending curvature and direction, which is essential for various applications such as structural health monitoring, mechanical deformation measurement, and shape sensing. In this work, we demonstrate a temperature-insensitive vector bending sensor via parallel Farby-Perot interferometers (FPIs) fabricated by etching and splicing a multicore fiber (MCF). The parallel FPIs made in this simple and effective way exhibit significant interferometric visibility with a fringe contrast over 20 dB in the reflection spectra, which is 6 dB larger than the previous MCF-based FPIs.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Clinical and Biological Sciences, University of Torino, 10043 Turin, Italy.
Background And Aims: Cancer cachexia is a complex syndrome affecting most cancer patients and is directly responsible for about 20% of cancer-related deaths. Previous studies showed muscle proteolysis hyper-activation and mitophagy induction in tumor-bearing animals. While basal mitophagy is required for maintaining muscle mass and quality, excessive mitophagy promotes uncontrolled protein degradation, muscle loss and impaired function.
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