Utilization of multiple-channel structure is a promising way of accomplishing high-throughput detections of analytes in solid-state pore sensors. Here we report on systematic investigation of particle capture efficiency in SiN multipore systems of various array configurations. We demonstrated enhanced detection throughput with increasing numbers of pore channels in a membrane. Meanwhile, we also observed significant contributions of the interchannel crosstalk in closely integrated multipores that tended to deteriorate throughput performance by causing shrinkage of the absorption zone via the interference-derived weakening of the electric field around the pore orifice. At the same time, the interference-derived electric field distributions were also found to diminish the electroosmotic contributions to the particle capture efficiency. The present findings can be useful in designing pore arrays with optimal throughput performance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acssensors.8b01214 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Control of Permanent Porosity in Type 3 Porous Liquids via Solvent Clustering.
ACS Appl Mater Interfaces
January 2025
Geochemistry Department, Sandia National Laboratories, Albuquerque, New Mexico 87123, United States.
Porous liquids (PLs) are an exciting new class of materials for carbon capture due to their high gas adsorption capacity and ease of industrial implementation. They are composed of sorbent particles suspended in a nonadsorbed solvent, forming a liquid with permanent porosity. While PLs have a vast number of potential compositions based on the number of solvents and sorbent materials available, most of the research has been focused on the selection of the sorbent rather than the solvent.
View Article and Find Full Text PDFCapturing eukaryotic ribosome dynamics in situ at high resolution.
Nat Struct Mol Biol
January 2025
Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Many protein complexes are highly dynamic in cells; thus, characterizing their conformational changes in cells is crucial for unraveling their functions. Here, using cryo-electron microscopy, 451,700 ribosome particles from Saccharomyces cerevisiae cell lamellae were obtained to solve the 60S region to 2.9-Å resolution by in situ single-particle analysis.
View Article and Find Full Text PDFA new platform of electrowetting-on-dielectric digital microfluidics for rapid detection of early-stage Hepatocellular Carcinoma(HCC) specific biomarker.
Anal Chim Acta
January 2025
School of Medical Technology, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address:
Background: The early detection of Hepatocellular Carcinoma (HCC) is crucial for improving patient survival rates.Early diagnosis of HCC can significantly enhance treatment outcomes and reduce disease progression. Antigen detection of tumor markers is one of the important diagnostic methods for HCC.
View Article and Find Full Text PDFUnderstanding the Kinetics of CO Hydrate Formation in Dry Water for Carbon Capture and Storage: X-ray Diffraction and In Situ Raman Studies.
ACS Appl Mater Interfaces
January 2025
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore.
Hydrate-based carbon capture and storage (HBCS) is a sustainable and promising approach to combating global warming by utilizing water, which is a ubiquitous resource. Here, we report a comprehensive study of CO hydrate formation in dry water (DW), a water-in-air dispersion confined in silica particles, for improving the kinetics of hydrate growth. Utilizing a combination of a home-built high-pressure reactor, in situ Raman spectroscopy, and powder X-ray diffraction (PXRD), we elucidate the crystal structure, growth dynamics, and morphology of CO hydrates formed in DW, with and without the kinetic hydrate promoter, l-tryptophan.
View Article and Find Full Text PDFBackground: There is a need for sensitive, robust, and scalable analytical methods for accurate, early detection of disease using less invasive sampling methods. Small volumes and low marker concentrations present challenges to achieving sufficient sensitivity and accuracy with traditional immunoassay methods - particularly when measuring markers for Alzheimer's (AD) and other neurological diseases in blood, where levels are typically much lower than in CSF. Here we introduce a novel optofluidic single-molecule counting platform for ultrasensitive detection of low-abundance biomarkers in plasma samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!