AI Article Synopsis
- Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a serious vascular condition primarily linked to chronic kidney disease (CKD) and can lead to severe skin and tissue complications.
- Diagnosis of CUA is challenging and relies on a high suspicion due to risks associated with biopsy, while imaging often shows extensive calcification in blood vessels, potentially resulting in gangrene.
- The disease is systemic and can affect multiple organs, with this text noting the first documented case involving the penis, bladder, and eyes.
Article Abstract
Calciphylaxis or calcific uremic arteriolopathy (CUA) is a potentially life-threatening vasculopathy involving the skin and subcutaneous tissues. It is usually associated with chronic kidney disease (CKD) and rarely with acute renal failure or predialysis patients. The clinical diagnosis of calcific uremic arteriolopathy relies on high index of suspicion. CUA is commonly associated with secondary hyperparathyroidism and high serum calcium and phosphate products. Moreover, using biopsy as a diagnostic tool is controversial, due to the high risk of poor wound healing and sepsis. Radiological studies usually reveal extensive calcification of branching vessels such as penile arteries, eventually leading to gangrene formation in extremities and penis. Histopathological analysis confirms the diagnosis of calcific uremic arteriolopathy and rules out the presence of malignancy. CUA is a systematic disease that involves multiple organs, and to the best of our knowledge this is the first reported case involving the penis, bladder, and eyes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211149 | PMC |
| http://dx.doi.org/10.1155/2018/9603680 | DOI Listing |
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