Smart Gold Nanoparticle-Stabilized Ultrasound Microbubbles as Cancer Theranostics.

J Mater Chem B

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA.

Published: May 2018

Smart gold nanoparticle-stabilized microbubbles (SAuMBs) composed of a gas-filled core and shell including smart gold nanoparticles (SAuNPs) which can be aggregated in tumors were applied as ultrasound-mediated cancer theranostics. The gas core in the microstructure enabled the detection of tumors using ultrasound and facilitated the delivery of SAuNPs by sonoporation. The SAuNPs spontaneously aggregated in tumors, which allowed photoacoustic (PA) monitoring and photothermal treatment (PTT) of tumors.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226101PMC
http://dx.doi.org/10.1039/C8TB00368HDOI Listing

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