We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322556 | PMC |
| http://dx.doi.org/10.1038/s41591-018-0238-9 | DOI Listing |
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