AI Article Synopsis
- - This study focused on understanding how integrons contribute to antibiotic resistance in Pseudomonas aeruginosa, particularly in ICU patients, with half of the 72 tested isolates coming from that setting.
- - Results showed that 76.4% of isolates were resistant to ceftazidime, while colistin was highly effective, with a 100% success rate; additionally, 55.5% of isolates had class 1 integrons and 29.1% had class 2 integrons.
- - A significant link was found between the presence of integrons and multidrug-resistant (MDR) isolates, with MDR observed in 73.6% of integron-positive isolates versus 22.9% in
Article Abstract
Objectives: The role of integrons in the transfer of antibiotic resistance is one of the important issues, therefore, this study is aimed to investigate antibiotic resistance pattern and prevalence of class 1 and 2 integrons in P. aeruginosa isolated.
Results: Out of 72 confirmed P. aeruginosa isolates, 50% were from ICU patients. Antibacterial susceptibility pattern showed that isolates were most resistant to ceftazidime (76.4%) and colistin was the most effective antibiotic (100%) and molecular analysis of class I and II integrons showed 55.5% and 29.1% of isolates were positive, respectively and the proportions of MDR isolates were significantly higher among integron-positive isolates with 73.6% compared to negative isolates with 22.9%. Our results showed that there was a correlation among class 1 and 2 integrons with MDR P. aeruginosa isolates. According to the importance of integrons in acquisition and dissemination of antibiotics resistance genes, the performance of antibiotic surveillance programs and investigating the role of integrons is recommended to control the spreading of antibiotics resistance genes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233361 | PMC |
| http://dx.doi.org/10.1186/s13104-018-3901-9 | DOI Listing |
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