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Evaluation of the interface of metallic-coated biodegradable polymeric stents with prokaryotic and eukaryotic cells.
Bioact Mater
April 2025
University of Coimbra, CEMMPRE, Department of Mechanical Engineering, 3030-788, Coimbra, Portugal.
Polymeric coronary stents, like the ABSORB™, are commonly used to treat atherosclerosis due to their bioresorbable and cell-compatible polymer structure. However, they face challenges such as high strut thickness, high elastic recoil, and lack of radiopacity. This study aims to address these limitations by modifying degradable stents produced by additive manufacturing with poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) with degradable metallic coatings, specifically zinc (Zn) and magnesium (Mg), deposited via radiofrequency (rf) magnetron sputtering.
View Article and Find Full Text PDFCurrent situation and overview of resorbable magnesium scaffolds: a perspective for overcoming the remaining issues of polymeric bioresorbable scaffold.
Cardiovasc Interv Ther
December 2024
Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Saitama, 330-8503, Japan.
Bioresorbable scaffolds (BRS) were developed as an innovative solution to overcome the limitations of metallic stents. While polymeric BRS initially demonstrated comparable clinical outcomes to drug-eluting stent (DES) in clinical trials, subsequent large-scale studies revealed that patients implanted with polymeric BRS experienced higher rates of scaffold thrombosis (ScT) and target lesion failure compared to those with metallic stents. Resorbable magnesium scaffolds (RMS) have emerged as a promising alternative owing to magnesium's natural degradability and favorable mechanical properties.
View Article and Find Full Text PDFPhysical exercise impacts bone remodeling around bio-resorbable magnesium implants.
Acta Biomater
December 2024
Aix-Marseille Univ, CNRS, Centrale Med, Institut Fresnel, 13013 Marseille, France. Electronic address:
Physical exercise has been shown to induce positive reactions in bone healing but next to nothing is known about how it affects the nanostructure, in particular around implants. In this study, we established this link by using small-angle X-ray scattering tensor tomography (SASTT) to investigate nanostructural parameters in 3D such as mineral particle orientation and thickness. As a model system, rat femoral bone with a bio-resorbable implant (ultra-high purity magnesium) was used.
View Article and Find Full Text PDFIn Vivo Study of Organ and Tissue Stability According to the Types of Bioresorbable Bone Screws.
Materials (Basel)
November 2024
Department of Orthopedics Surgery, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
Biodegradable material, such as magnesium alloy or polylactic acid (PLA), is a promising candidate for orthopedic surgery. The alloying of metals and the addition of rare earths to increase mechanical strength are still questionable in terms of biosafety as absorbent materials. Therefore, the purpose of this study is to understand the effect of substances due to the degradation of various biodegradable substances on organs in the body or surrounding tissues.
View Article and Find Full Text PDFPerformance evaluation of a low-cost Ti-Mo-Fe (TMF8) as a replacement for Ti-6Al-4V for internal fixation implants used in mandibular angular fractures: a finite element analysis study.
J Mater Sci Mater Med
November 2024
Department of Materials Science and Engineering, Egypt-Japan University of Science and Technology, New Borg El-Arab City, Alexandria, Egypt.
Stainless steel and titanium-based alloys have been the gold standard when it comes to permanent implants and magnesium-based alloys have been the best option for bioresorbable alloys. Ti-6Al-4V, Ti-64, with its 110 GPa Young's Modulus is the most commonly employed alloy to manufacture biomedical implants used for treatment of fractures of skeleton. Recently, researchers have developed a new low-cost and toxic Vanadium-free alternative to this alloy, Ti-3Mo-0.
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