Neuroprotective terpenoids from the leaves of .

As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (-), along with five known terpenoids (-), were isolated from the dry leaves of Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against HO-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis.[Formula: see text].