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Pharmacological characterizations of the 'legal high' fluorolintane and isomers.
Eur J Pharmacol
August 2019
Department of Pharmaceutical Sciences, University of the Sciences, Philadelphia, PA, USA; Department of Chemistry and Biochemistry, University of the Sciences, Philadelphia, PA, USA.
1,2-Diarylethylamines represent a class of molecules that have shown potential in the treatment of pain, epilepsy, neurodegenerative disease and depression. Examples include lefetamine, remacemide, and lanicemine. Recently, several 1,2-diarylethylamines including the dissociatives diphenidine, methoxphenidine and ephenidine as well as the opioid MT-45, have appeared as 'research chemicals' or 'legal highs'.
View Article and Find Full Text PDFEphenidine, diphenidine and methoxphenidine complications reported to the French Addictovigilance Network: another brick in the wall!
Fundam Clin Pharmacol
December 2018
The Paris' Federation of Toxicology (FeTox), AP-HP, Lariboisière and Fernand-Widal Hospitals, Paris-Diderot University, INSERM UMRS-1144, Paris, France.
Ephenidine, diphenidine, and methoxphenidine complications reported to the French Addictovigilance Network.
Fundam Clin Pharmacol
December 2018
Département de Pharmacologie Médicale et Toxicologie, Centre d'Addictovigilance, CHRU de Montpellier, 34294, Montpellier Cedex, France.
Ephenidine, diphenidine, and methoxphenidine belong to the family of diarylethylamines that are psychoactive substances derived from lefetamine (N, N-di-methyl-1,2-diphenylethylamine, also called L-SPA). These dissociative anesthetic compounds act as potent and selective N-methyl-d-aspartate receptor antagonists and were recently classified as narcotic drugs in France. The available data suggest a significant risk of psychic and somatic complications.
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