Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Interleukin-12 therapy restores cell-mediated immunity in ethanol-consuming mice.
Alcohol Clin Exp Res
February 1998
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611-3072, USA.
Previous studies from our laboratory show that ethanol consumption impairs antigen-specific, cell-mediated, but not, humoral immune responses of C57BL/6, BALB/c, and DO11.10 T-cell receptor transgenic mice. This ethanol-associated deficit is associated with decreased interleukin (IL)-12 and interferon-gamma (IFN-gamma) production, but not IL-2 or antigen-specific T-cell proliferation by explanted leukocytes from ethanol-consuming mice.
View Article and Find Full Text PDFThe influence of age on blood alcohol levels and ethanol-associated immunosuppression in a murine model of ethanol consumption.
Alcohol Clin Exp Res
April 1993
Department of Microbiology, University of Texas Medical Branch, Galveston.
Several study findings indicate that with ethanol ingestion a number of changes occur in the immune system. We studied the effects of ethanol consumption on mice at various ages. We used a murine model in which young (age 6-8 weeks), middle-aged (age 12 months), and old (age 24 months) male C57Bl/6 mice were pair-fed either a Leiber-DeCarli liquid diet containing 7% (v/v) ethanol or an isocaloric control diet.
View Article and Find Full Text PDFEffect of adrenalectomy on ethanol-associated immunosuppression.
Int J Immunopharmacol
October 1990
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
The alterations in lymphoid cell numbers and lymphocyte function due to administration of ethanol was found to be associated with high levels of circulating corticosteroids. The role of corticosteroids in the ethanol-induced alterations in the immune system was studied by administering ethanol to adrenalectomized rats. The results of these experiments showed that the ethanol-induced loss of cells from the thymus was not completely prevented by adrenalectomy and the ethanol-induced loss of cells from the spleen was not affected by adrenalectomy.
View Article and Find Full Text PDFMechanisms of suppression of cellular immunity induced by ethanol.
Alcohol Clin Exp Res
August 1989
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Previous study findings from this laboratory and other laboratories have established that ethanol administration to experimental animals or ingestion by human beings results in many changes in the immune system. The major effort in this laboratory is the study of the mechanisms by which ethanol down-regulates the responses of thymus-derived lymphocytes. By using a rat model of ethanol intoxication we have described a defect in lymphocyte proliferation to concanavalin A.
View Article and Find Full Text PDFEthanol, immunomodulation and cancer.
Prog Food Nutr Sci
January 1989
Department of Family and Community Medicine, University of Arizona, Tucson 85724.
Several major physiological changes or disease states occur more frequently in alcohol abusers or prolonged high users. These include: cancer, immunosuppression, and nutritional deficiencies. They interact with potential enhancement of cancer growth or survival.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!