AI Article Synopsis
- Verrucous carcinoma (VC) is a rare, low-grade variant of squamous cell carcinoma (SCC), making up 3%-8% of penile SCC cases.
- A case study describes a paraplegic man with destructive VC affecting the glans penis, resulting in a condition called hypospadias.
- Histological examination revealed distinctive growth patterns, and in situ hybridization tests showed positivity for both low-risk and high-risk strains of human papillomavirus.
Article Abstract
Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Histology demonstrated exophytic squamous epithelial proliferation with characteristic round, pushing borders. In situ hybridization was positive for both low-risk and high-risk strains of human papillomavirus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217864 | PMC |
| http://dx.doi.org/10.7759/cureus.3244 | DOI Listing |
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