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Preserved but Un-Sustained Responses to Bids for Dyadic Engagement in School-Age Children with Autism.
J Autism Dev Disord
January 2025
Center for Child Health, Behavior and Development, Seattle Children's Research Institute, 1920 Terry Ave CURE-3, Seattle, WA, 98101, USA.
Purpose: Dynamic eye-tracking paradigms are an engaging and increasingly used method to study social attention in autism. While prior research has focused primarily on younger populations, there is a need for developmentally appropriate tasks for older children.
Methods: This study introduces a novel eye-tracking task designed to assess school-aged children's attention to speakers involved in conversation.
Tracking the Geometric and Positional Isomerization of Lipid C═C Bonds in the Bacterial Stress Responses by Mass Spectrometry.
Anal Chem
January 2025
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China.
The position and configuration of the C═C bond have a significant impact on the spatial conformation of unsaturated lipids, which subsequently affects their biological functions. Double bond isomerization of lipids is an important mechanism of bacterial stress response, but its in-depth mechanistic study still lacks effective analytical tools. Here, we developed a visible-light-activated dual-pathway reaction system that enables simultaneous [2 + 2] cycloaddition and catalytic - isomerization of the C═C bond of unsaturated lipids via directly excited anthraquinone radicals.
View Article and Find Full Text PDFThe Visual Integration of Semantic and Spatial Information of Objects in Naturalistic Scenes (VISIONS) database: attentional, conceptual, and perceptual norms.
Behav Res Methods
January 2025
Department of Psychology, Sapienza, University of Rome, Rome, Italy.
The complex interplay between low- and high-level mechanisms governing our visual system can only be fully understood within ecologically valid naturalistic contexts. For this reason, in recent years, substantial efforts have been devoted to equipping the scientific community with datasets of realistic images normed on semantic or spatial features. Here, we introduce VISIONS, an extensive database of 1136 naturalistic scenes normed on a wide range of perceptual and conceptual norms by 185 English speakers across three levels of granularity: isolated object, whole scene, and object-in-scene.
View Article and Find Full Text PDFExposure of Young Mice to Atmospherically Relevant PM Has Sex-Dependent Long-Lasting Impacts on the Skeletal Muscle System.
Aging Dis
December 2024
Department of Sports Science, College of Natural Science, Jeonbuk National University, Jeonju 54896, Korea.
The negative effects of particulate matter up to 2.5 μm in diameter (PM) and their mediating mechanisms have been studied in various tissues. However, little is known about the mechanism and long-term tracking underlying the sex-dependent effects of PM on skeletal muscle system modulation.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Dept of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Recent Alzheimer's disease (AD) genome-wide association studies () have identified >75 risk loci, with >98% of genome-wide significant variants residing in non-coding genomic regions, making it more difficult to infer their functional contexts. In this study, we aim to jointly 1) fine-map causal loci/variants, and 2) identify affected cell types and functional elements by interrogating large-scale collections of thousands of heterogenous, cell type-specific functional genomic (FG) datasets.
Method: We analyzed the full genome-wide summary statistics (n = 21,101,114 variants) from the recent AD GWAS (Bellenguez et al, 2022) (Ncases = 111,326, Ncontrols = 677,663).
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