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Opioid withdrawal syndrome induced by naldemedine administration in a cancer patient without brain metastasis.
Palliat Support Care
March 2025
Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.
Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.
Effectiveness of Switching from Multiple-Inhaler to Once-Daily Single-Inhaler Triple Therapy in Patients with COPD in a Real-World Setting in Japan.
Int J Chron Obstruct Pulmon Dis
March 2025
Real World Data Analytics, Japan Development, GSK, Tokyo, Japan.
Purpose: Following the relatively recent introduction of single-inhaler triple therapies in Japan, this study compared the effectiveness of switching from multiple-inhaler triple therapy (MITT) to once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) by investigating COPD exacerbations and adherence among patients with chronic obstructive pulmonary disease (COPD) in Japan.
Methods: This retrospective, pre-post cohort study using the Medical Data Vision Co. Ltd database identified patients with ≥1 inpatient diagnosis and/or ≥2 outpatient diagnoses of COPD at age ≥40 years prior to the index date (first/earliest date of single-inhaler FF/UMEC/VI initiation from May 1, 2019-February 28, 2022, following a switch from MITT).
Myositis of pterygoid muscles and superior ophthalmic vein and cavernous sinus thrombosis in active Crohn's disease undergoing ustekinumab treatment: a case report and literature review.
Front Pharmacol
February 2025
Department of Pediatric Gastroenterology and Hepatology and nutrition, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Introduction: Myositis is a rare extra-intestinal presentation in patients with inflammatory bowel diseases (IBD), and its occurrence has only been described in a few case reports. However, it is essential to consider other potential causes as patients with IBD are more susceptible to infections due to their immunocompromised status, which may also be exacerbated by immunosuppressive drugs contributing to myositis. Our case highlights the complexity and challenges in diagnosing and managing myositis in patients with IBD as well as a review of the literature.
View Article and Find Full Text PDFProlonged Neuromuscular Blockade Following Succinylcholine Administration and the Clinical Importance of Family History: A Case Report.
Cureus
February 2025
Anesthesiology, HCA Florida Westside Hospital, Plantation, USA.
When evaluating the etiology of delayed emergence from anesthesia, several differential diagnoses must be considered, with family history often being an overlooked factor. This case report highlights the clinical significance and diagnostic challenges of one such differential - pseudocholinesterase deficiency (PD). PD is a known defect in the pseudocholinesterase enzyme that may be either inherited or acquired.
View Article and Find Full Text PDFKorean Guidelines for Diagnosis and Management of Interstitial Lung Disease: Cryptogenic organizing pneumonia.
Tuberc Respir Dis (Seoul)
March 2025
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
Cryptogenic organizing pneumonia (COP), one of the idiopathic interstitial pneumonias (IIP), exhibits an acute or subacute course. It can be diagnosed after excluding secondary causes or diseases. COP accounts for approximately 5-10% of IIPs, with the average age of diagnosis ranging from 50 to 60 years.
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