Invention Versus Gold Standard: A Hands-On Research Pearl on Study Design and Statistical Concerns.

Arthroscopy

UConn Health, Farmington, Connecticut, U.S.A.

Published: December 2018

This article points out what is important to consider when planning to perform and analyze a commonly seen study involving a comparison of an innovation with something established. A hands-on guide on how to perform this type of research trial and how to choose proper statistical methods is given.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arthro.2018.08.044DOI Listing

Publication Analysis

Top Keywords

versus gold
4
gold standard
4
standard hands-on
4
hands-on pearl
4
pearl study
4
study design
4
design statistical
4
statistical concerns
4
concerns article
4
article points
4

Similar Publications

Background: Randomised controlled trials are widely accepted as the gold standard research methodology for the evaluation of interventions. However, they often display poor participant retention. To prevent this, various participant interventions have been identified and evaluated through the use of studies within a trial.

View Article and Find Full Text PDF

This study explores the development of a photo-responsive bicomponent electrospun platform and its drug delivery capabilities. This platform is composed of two polymers of poly(lactide-co-glycolide) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). Then, the platform is decorated with plasmonic gold nanostars (Au NSs) that are capable of on-demand drug release.

View Article and Find Full Text PDF

Background: Stroke is the leading cause of adult disability worldwide, with approximately 30% of strokes remaining cryptogenic. One potential important etiology is a patent foramen ovale (PFO), which may contribute to stroke through paradoxical thromboembolism or thromboembolus formation. Recent advancements in robot-assisted transcranial Doppler (raTCD) have shown increased sensitivity in detecting right-to-left shunt (RLS) compared to transthoracic echocardiography (TTE), particularly in detecting the large shunts which are associated with higher stroke risk.

View Article and Find Full Text PDF

Introduction: Assessing the severity of mitral stenosis (MS) is crucial for predictive and therapeutic purposes. While methods like planimetry and Pressure half time (PHT) are considered gold standard for measuring mitral valve area (MVA), they can be operator-dependent or influenced by hemodynamic factors. Our study evaluates the accuracy of mitral leaflet separation index (MLSI) as an alternative tool for assessing rheumatic MS severity, considering its independence from hemodynamic variations.

View Article and Find Full Text PDF
Article Synopsis
  • Australia and New Zealand have the highest skin cancer rates globally, particularly in non-metropolitan areas, with Mohs micrographic surgery (MMS) being the preferred treatment for keratinocyte cancers due to its effective cure rates and reduced tissue loss.
  • This study analyzed MMS cases from The Skin Hospital in 2017, comparing tumour and defect sizes between patients from the Sydney Metropolitan Area (SMA) and those from Outside Metropolitan Sydney (OMS), including further breakdown of OMS into Non-Sydney Metropolitan (NSM) and Regional, Rural, and Remote (RRR) groups.
  • Results indicated that OMS patients had larger tumours and defects than SMA patients, suggesting that patients outside major cities face barriers to accessing timely specialized care, highlighting the need
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!