This article points out what is important to consider when planning to perform and analyze a commonly seen study involving a comparison of an innovation with something established. A hands-on guide on how to perform this type of research trial and how to choose proper statistical methods is given.
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http://dx.doi.org/10.1016/j.arthro.2018.08.044 | DOI Listing |
Clin Trials
March 2025
Warwick Clinical Trials Unit, Warwick Medical School, The University of Warwick, Coventry, UK.
Background: Randomised controlled trials are widely accepted as the gold standard research methodology for the evaluation of interventions. However, they often display poor participant retention. To prevent this, various participant interventions have been identified and evaluated through the use of studies within a trial.
View Article and Find Full Text PDFMacromol Rapid Commun
March 2025
Institute of Fundamental Technological Research, Polish Academy of Sciences, ul. Pawińskiego 5B, Warsaw, 02-106, Poland.
This study explores the development of a photo-responsive bicomponent electrospun platform and its drug delivery capabilities. This platform is composed of two polymers of poly(lactide-co-glycolide) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). Then, the platform is decorated with plasmonic gold nanostars (Au NSs) that are capable of on-demand drug release.
View Article and Find Full Text PDFFront Neurol
February 2025
Catholic Health Initiatives (CHI) Memorial Neuroscience Institute, Morehouse School of Medicine, Chattanooga, TN, United States.
Background: Stroke is the leading cause of adult disability worldwide, with approximately 30% of strokes remaining cryptogenic. One potential important etiology is a patent foramen ovale (PFO), which may contribute to stroke through paradoxical thromboembolism or thromboembolus formation. Recent advancements in robot-assisted transcranial Doppler (raTCD) have shown increased sensitivity in detecting right-to-left shunt (RLS) compared to transthoracic echocardiography (TTE), particularly in detecting the large shunts which are associated with higher stroke risk.
View Article and Find Full Text PDFIntroduction: Assessing the severity of mitral stenosis (MS) is crucial for predictive and therapeutic purposes. While methods like planimetry and Pressure half time (PHT) are considered gold standard for measuring mitral valve area (MVA), they can be operator-dependent or influenced by hemodynamic factors. Our study evaluates the accuracy of mitral leaflet separation index (MLSI) as an alternative tool for assessing rheumatic MS severity, considering its independence from hemodynamic variations.
View Article and Find Full Text PDFAustralas J Dermatol
March 2025
The Skin Hospital, Westmead, New South Wales, Australia.
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