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Voltage-sensitive calcium channels contribute to depolarization of both motor- and interneurons in animal studies, but less is known of their contribution to human motor control and whether blocking them has potential in future antispasmodic treatment in humans. Therefore, this study investigated the acute effect of Nimodipine on the transmission of human spinal reflex pathways involved in spasticity. In a double-blinded, cross-over study, we measured soleus muscle stretch- and H-reflexes, and tibialis anterior cutaneous reflexes in nineteen healthy subjects before and after Nimodipine (tab-let 60mg) or Baclofen (tablet 25mg).
View Article and Find Full Text PDFEfficacy of multimodal treatment involving Baclofen, pelvic floor physiotherapy and polysomnography for sleep related painful erections (SRPE): a single centre observational cohort study.
Int J Impot Res
December 2024
Guy's and St Thomas' NHS Foundation Trust, London, UK.
Sleep Related Painful Erections (SRPE) are parasomnias exclusive to Rapid Eye Movement (REM) sleep, causing sleep disturbances, daytime fatigue, and impaired quality of life. Due to a lack of standardized management, we developed a diagnostic and treatment pathway for this rare condition at our institution. Patients diagnosed with SRPE from 2017-2024 by strict criteria were recruited into our novel pathway.
View Article and Find Full Text PDFModern pharmacotherapy guidance for treating alcohol use disorders.
Expert Opin Pharmacother
December 2024
Forel Clinic, Addiction Treatment Center, Switzerland.
Introduction: Alcohol use disorder (AUD) is prevalent and recognized as a chronic, relapsing disorder. Even though effective treatment options are available, AUD is strongly undertreated. As adjuvant treatment strategies accompanying psychosocial treatments, pharmacological strategies can increase the efficacy of AUD treatment options.
View Article and Find Full Text PDFEfficacy of sodium oxybate plus disulfiram for the maintenance of alcohol abstinence in treatment-resistant patients with alcohol use disorder: a multicentre retrospective study.
Ann Ist Super Sanita
December 2024
Dipartimento di Medicina Traslazionale e per la Romagna, Università di Ferrara, Ferrara, Italy.
Introduction: Disulfiram (DF), acamprosate, naltrexone, baclofen and sodium oxybate (SO) are currently the medications approved for the treatment of alcohol use disorder (AUD). In this context, combined pharmacological interventions and sex differences are an interesting area in the treatment of non-responder AUD patients.
Aim: To evaluate the efficacy of SO in combination with DF in maintaining alcohol abstinence in patients with AUD who failed to achieve abstinence either with SO or DF alone.
The Use of Baclofen to Control Vertical Nystagmus in a Patient with Advanced Glioma: A Case Report.
J Hosp Palliat Care
December 2024
Department of Palliative Care, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, SAU.
Nystagmus, characterized by involuntary eye movements, can arise from several causes, with benign paroxysmal positional vertigo being the most prevalent. Additionally, central lesions such as tumors may also induce nystagmus. This case report describes the amelioration of vertical nystagmus in a patient with advanced glioma after treatment with the GABAergic drug baclofen.
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