The striking rise of methicillin-resistant (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant A. Gray, which led to the isolation of two new sesquiterpene alkaloids ( and ) and six known furanosesquiterpenes (⁻). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids ( and ) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of genus and their anti-MRSA activity.
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| http://dx.doi.org/10.3390/md16110438 | DOI Listing |
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