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Caffeine improves bladder function in streptozotocin-induced diabetic rats. | LitMetric

AI Article Synopsis

  • The study aimed to investigate the protective effects of caffeine on bladder function in diabetic rats using urodynamic tests.
  • Female Sprague-Dawley rats with diabetes, induced by a chemical, were divided into different treatment groups including a caffeine treatment at two dosages (5 and 10 mg/kg/day).
  • Results showed that caffeine significantly improved bladder function parameters such as reducing bladder capacity and residual urine, while increasing voiding efficiency in diabetic rats after 8 weeks.

Article Abstract

Aims: To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics.

Methods: Female Sprague-Dawley rats (n = 24) were divided into four groups: control group, DM group, DM + caffeine (5 mg/kg/day), and DM + caffeine (10 mg/kg/day). DM was induced by streptozotocin (STZ). Cystometric studies were conducted on all rats. After 8 weeks of treatment with caffeine, the urodynamic parameters, including bladder capacity, residual urine volume, voiding time, and peak voiding pressure, were measured.

Results: DM rats had a higher bladder capacity and post-void residual urine volume (PVR), an increased voiding time and peak voiding pressure, and a markedly lower voiding efficiency than the control group rats. After treatment with caffeine, bladder capacity, post-void residual urine volume, and peak voiding pressure were significant lower than those in the DM group, but voiding efficiency was markedly higher.

Conclusion: The results suggested that caffeine (5 or 10 mg/kg/day) may improve the bladder function at 8 weeks after STZ induction. Thus, this may represent a potential strategy to increase voiding efficiency in diabetes.

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Source
http://dx.doi.org/10.1002/nau.23799DOI Listing

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