Purpose: To evaluate the visual, refractive, and topographic outcomes after simultaneous topography-guided transepithelial photorefractive keratectomy (transepithelial TG-PRK) using the Amaris Excimer laser platform and accelerated corneal cross-linking (CXL) in eyes with keratoconus.

Materials And Methods: Patients with 2 years of follow-up were included in this retrospective case series. Manifest refraction (MR), uncorrected (UDVA) and corrected (CDVA) distance visual acuity, corneal topography, and pachymetry were evaluated at 1, 3, 6, 12, and 24 months after surgery. The root-mean-square of total higher-order aberrations (total HOA-RMS), coma (Coma-RMS), and spherical aberration (SA-RMS) were calculated for 4- and 6-mm diameters.

Results: Forty-six eyes of 46 patients were included in the study. Stromal ablation was ≤50 in all patients. MR was -3.78±3.26 preoperatively and -1.39±1.82 postoperatively. Significant improvements were seen in the UDVA and Coma-RMS values at 1 month, CDVA and total HOA-RMS values at 3 months, and SA-RMS values at 1 year compared to preoperative levels. UDVA values further improved after 2 years, compared to the 1-year values. No patient lost two or more lines and keratoconus progression was not observed in any patient.

Conclusion: Simultaneous transepithelial TG-PRK and accelerated CXL resulted in significant gains in CDVA without compromising CXL efficacy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205309PMC
http://dx.doi.org/10.1155/2018/2945751DOI Listing

Publication Analysis

Top Keywords

simultaneous transepithelial
8
photorefractive keratectomy
8
transepithelial tg-prk
8
total hoa-rms
8
values
5
transepithelial topography-guided
4
topography-guided photorefractive
4
keratectomy accelerated
4
accelerated cross-linking
4
cross-linking keratoconus
4

Similar Publications

Fluorinated chitosan mediated transepithelial delivery of sanguinarine-loaded platinum (IV) prodrug for intravesical instillation therapy of muscle-invasive bladder cancer.

J Control Release

December 2024

Department of Urology, South China Hospital, Medical School, Shenzhen University, Shenzhen 518116, China; Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, China. Electronic address:

Cisplatin-based neoadjuvant chemotherapy is first-line strategy to inhibit progression and metastasis of muscle-invasive bladder cancer (MIBC). However, its clinical efficacy is often limited by drug resistance and severe systemic side effects, highlighting the urgent need for innovative therapeutic approaches. Despite advancements in cisplatin-based regimens, research on intravesical cisplatin delivery systems remains scarce.

View Article and Find Full Text PDF
Article Synopsis
  • Traditional inhalation toxicity tests for respiratory chemicals often rely on animal testing, leading to ethical concerns and limitations due to anatomical differences and complex processes.
  • This study developed an alternative method using a co-culture system with differentiated epithelial cells and fibroblasts to mimic the human respiratory wound-healing process.
  • The new multi-analysis model effectively measures toxicological responses and functional assessments, showing significant changes such as cytotoxicity and reduced cilia motility, indicating its potential for more accurate predictions of pulmonary toxicity.
View Article and Find Full Text PDF

Organ chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels.

Biosens Bioelectron

December 2024

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA; Vascular Biology Program and Department of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address:

Despite remarkable advances in Organ-on-a-chip (Organ Chip) microfluidic culture technology, recreating tissue-relevant physiological conditions, such as the region-specific oxygen concentrations, remains a formidable technical challenge, and analysis of tissue functions is commonly carried out using one analytical technique at a time. Here, we describe two-channel Organ Chip microfluidic devices fabricated from polydimethylsiloxane and gas impermeable polycarbonate materials that are integrated with multiple sensors, mounted on a printed circuit board and operated using a commercially available Organ Chip culture instrument. The novelty of this system is that it enables the recreation of physiologically relevant tissue-tissue interfaces and oxygen tension as well as non-invasive continuous measurement of transepithelial electrical resistance, oxygen concentration and pH, combined with simultaneous analysis of cellular metabolic activity (ATP/ADP ratio), cell morphology, and tissue phenotype.

View Article and Find Full Text PDF
Article Synopsis
  • * A new device called a "ventilator-on-a-chip" (VOC) has been developed to mimic lung conditions and can measure how mechanical forces, like over-distention and surface tension during reopening, affect lung barrier integrity.
  • * The study showed that while over-distention has a recoverable impact on lung barriers, surface tension forces from airway reopening cause more significant and prolonged damage, highlighting the VOC's ability to investigate and monitor VILI in real-time.
View Article and Find Full Text PDF

Several blinding diseases affecting the retina and optic nerve are exacerbated by or caused by dysregulated inflammation and oxidative stress. These diseases include uveitis, age related macular degeneration, diabetic retinopathy and glaucoma. Consequently, despite their divergent symptoms, treatments that reduce oxidative stress and suppress inflammation may be therapeutic.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!