A series of propargylamides containing an electron-rich benzene ring was prepared through the Ugi reaction of 3,5-dimethoxyaniline with various propiolic acids, aldehydes and isocyanides. Subjecting these adducts to a gold-catalyzed intramolecular alkyne hydroarylation process allowed to efficiently construct the 2-quinolone core bearing a branched substituent on the nitrogen atom.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204774 | PMC |
| http://dx.doi.org/10.3762/bjoc.14.234 | DOI Listing |
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