AI Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver issue in kids and can lead to severe complications like cirrhosis and liver cancer, but we lack a clear understanding of its progression and effective treatments.
- The EU-PNAFLD is a multi-centre registry that aims to track the natural history of paediatric NAFLD while collecting samples for future research, including genome studies.
- By collaborating with the adult European NAFLD Registry, EU-PNAFLD will gather long-term clinical outcome data, helping to answer critical questions about paediatric NAFLD and improve patient care.
Article Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in children and has the potential to progress to advanced fibrosis/cirrhosis, end-stage liver disease and hepatocellular carcinoma. However, the natural history of the condition is poorly understood and there are no approved treatments. The European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD) is a multi-centre registry of paediatric NAFLD that will serve as a prospective, observational, natural history study and provide a tractable back-bone to support recruitment into subsequent interventional trials. Collection of samples into a bio-repository will facilitate translational studies, including genome sequencing and metabolomics. EU-PNAFLD will work closely alongside the existing adult European NAFLD Registry to obtain data on clinical outcomes after 20-30 years. Through an international, well-characterised large-scale cohort, EU-PNAFLD will address the key questions in paediatric NAFLD and benefit patients with the condition.
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| http://dx.doi.org/10.1016/j.cct.2018.11.003 | DOI Listing |
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