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Pseudo-Chediak-Higashi inclusions and Auer rods in a case of therapy-related acute monocytic leukemia.
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Objectives: This study aimed to determine the frequency of RUNX1/RUNX1T1 gene rearrangement in acute myeloid leukemia (AML) patients by polymerase chain reaction (PCR) and analyze their clinical, hematological, and morphological features of positive patients.
Patients And Methods: A cross-sectional study was conducted in which newly diagnosed patients with AML were included in the study. A total of 101 AML cases were calculated from the World Health Organization (WHO) formula.
Second trimester medical abortion in acute promyelocytic leukaemia.
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View Article and Find Full Text PDFAssessing the accuracy and clinical utility of GPT-4O in abnormal blood cell morphology recognition.
Digit Health
November 2024
Department of Clinical Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Article Synopsis
- The study evaluated GPT-4O's ability to recognize abnormal blood cell morphology, an important aspect of hematologic diagnosis, and compared its performance to experienced hematologists.
- GPT-4O showed a 70% accuracy rate, which was significantly lower than the 95.42% accuracy of hematologists, highlighting its limitations in clinical effectiveness.
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[Analysis of Morphologic Classification System for Acute Promyelocytic Leukemia and Its Correlation with Laboratory Tests and Mutation].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2024
Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Objective: To establish a morphologic classification system for characterizing blast cells in patients with acute promyelocytic leukemia (APL) and analyze the correlation of different APL morphologic characteristics with conventional tests and genetic variants.
Methods: Based on the morphological characteristics of APL blast cells, a classification system of 14 categories was established to characterize the inter- and intra-individual cellular morphological heterogeneity of patients. The classification system was used for the morphological analysis of 40 APL patients, and the classification results were statistically analyzed with the patients' conventional test indexes and gene variant characteristics to analyze the correlation of different APL blast cell morphological features with conventional test indexes and gene variants.
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