Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells.

Leuk Lymphoma

b Centro de Investigación en Bioquímica Clínica e Inmunología (CIBICI-CONICET) Facultad de Ciencias Químicas , Universidad Nacional de Córdoba , Córdoba , Argentina.

Published: May 2019

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2018.1529309DOI Listing

Publication Analysis

Top Keywords

effects rapamycin
4
rapamycin combination
4
combination fludarabine
4
fludarabine primary
4
primary chronic
4
chronic lymphocytic
4
lymphocytic leukemia
4
leukemia cells
4
effects
1
combination
1

Similar Publications

Background: Non-clear cell renal cell carcinoma (nccRCC) represents a heterogeneous group of malignancies with substantial differences in morphology, genetic profiles, clinical behavior, and prognosis. Optimal treatment for nccRCC remains unclear, largely extrapolated from evidence available for clear cell renal cell carcinoma (ccRCC). This study aimed to compare the efficacy of current mainstream drug treatments for nccRCC to provide clinical treatment guidance for advanced cases.

View Article and Find Full Text PDF

Diabetic liver injury is a serious complication due to the lack of effective treatments and the unclear pathogenesis. Ferroptosis, a form of cell death involving reactive oxygen species (ROS)-dependent lipid peroxidation (LPO), is closely linked to autophagy and diabetic complications. Therefore, this study is aimed at investigating the role of autophagy in regulating ferroptosis by modulating the degradation of acyl-CoA synthetase long-chain family member 4 (ACSL4) in diabetic hepatocytes and its potential impact on diabetic liver injury.

View Article and Find Full Text PDF

Acute liver failure (ALF) is a fulminant clinical syndrome that usually leads to multiple organ failure and high mortality. Macrophages play a crucial role in the initiation, development, and recovery of ALF. Targeting macrophages through immunotherapy holds significant promise as a therapeutic strategy.

View Article and Find Full Text PDF

VNS paired with training enhances recognition memory: mechanistic insights from proteomic analysis of the hippocampal synapse.

Front Mol Neurosci

December 2024

Cognitive Neuroscience, 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, United States.

Introduction: Recognition memory, an essential component of cognitive health, can suffer from biological limitations of stress, aging, or neurodegenerative disease. Vagus nerve stimulation (VNS) is a neuromodulation therapy with the potential to improve cognitive function. This study investigated the effectiveness of multiple sessions of VNS to enhance recognition memory in healthy rodents and the underlying cognitive benefits of VNS by proteomic analysis of the synaptosome.

View Article and Find Full Text PDF

Lymphangioleiomyomatosis (LAM) is a rare, low-grade malignant condition that typically affects women of childbearing age and primarily involves the lungs. While cases involving males and affecting the gastrointestinal tract are exceedingly uncommon. This report discusses an unusual case of abdominal LAM in a male patient with gastrointestinal hemorrhage.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!