Using signal detection theory, we investigated whether human participants represent time linearly or logarithmically in a bisection task. Participants saw a stimulus 1.0 to 1.5 s in duration, and then judged whether the stimulus duration was closer to 1.0 s or to 1.5 s, and how sure they were of their response. Whereas the mean of the subjective stimulus duration was a linear function of the objective stimulus duration, participants produced remarkably different psychophysical functions-linear for some participants, concave for others, and convex for still others. Hence, the appropriate question might not be whether humans encode time linearly or logarithmically, but for which participants and under which conditions is time encoded linearly, logarithmically, or even exponentially. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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Alzheimers Dement
December 2024
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Background: Microglia play an important role in immune memory. Lipopolysaccharide (LPS) triggers immune memory and primes microglia, resulting in brain pathologies and brain dysfunction following a second stimulus (1, 2). An increase in the C1q/ PSD95 expressions within microglia and excessively synaptic pruning were observed in mouse model of Alzheimer's disease (3).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute on Aging/National Institutes of Health (NIA/NIH), Baltimore, MD, USA.
Background: Early vascular aging (EVA), manifesting as increases in central arterial stiffness and BP, is associated with cognitive impairment in humans. EVA and cognitive impairment occurs in Dahl salt-sensitive (DSS) rats consuming a normal salt (NS) diet with an advancing age. Quercetin (QRC), a flavonoid with anti-oxidant, anti-inflammatory and senolytic properties, previously shown to reduce salt-sensitive hypertension in DSS.
View Article and Find Full Text PDFOphthalmic Physiol Opt
December 2024
School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
Purpose: To assess the ability of the Dolphin air-pulse aesthesiometer to present multiple stimuli, which are separated temporally (in sequence) or spatially (simultaneously).
Methods: Two studies were performed to explore the cooling effects induced by double air-puff stimuli generated by a novel aesthesiometer composed of two micro-blower integrated units. The stimuli were delivered sequentially or simultaneously at the same or different spatial locations to an in vitro eye model monitored using thermography.
Photoacoustics
February 2025
College of Control Science & Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. Herein, we present a novel optomechanical energy-enhanced (OEE-) BF-QEPAS technique for fast and sensitive gas sensing. Our approach employs periodic pulse-width modulation (PWM) of the laser signal with an optimized duty cycle, maintaining the quartz tuning fork's (QTF) output at a stable steady-state level by applying stimulus signals at each half-period and allowing free vibration in alternate half-periods to minimize energy dissipation.
View Article and Find Full Text PDFActa Psychol (Amst)
December 2024
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Affective Theory of Mind (ToM) is the ability to understand other peoples' emotional states and feelings. Several studies showed impaired affective ToM abilities in people with Parkinson's disease (PD). However, most studies tested this ability by using single-stimulus modality tasks (visual cues).
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