Adipsin, MIP-1b, and IL-8 as CSF Biomarker Panels for ALS Diagnosis.

Dis Markers

Tecnologico de Monterrey, Ave. Morones Prieto 3000, Escuela de Medicina y Ciencias de la Salud, Monterrey, NL, 64710, Mexico.

Published: February 2019

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that selectively attacks motor neurons in the brain and spinal cord. Despite important advances in the knowledge of the etiology and progression of the disease, there are still no solid grounds in which a clinician could make an early objective and reliable diagnosis from which patients could benefit. Diagnosis is difficult and basically made by clinical rating scales (ALSRs and El Escorial). The possible finding of biomarkers to aid in the early diagnosis and rate of disease progression could serve for future innovative therapeutic approaches. Recently, it has been suggested that ALS has an important immune component that could represent either the cause or the consequence of the disease. In this report, we analyzed 19 different cytokines and growth factors in the cerebrospinal fluid of 77 ALS patients and 13 controls by decision tree and PanelomiX program. Results showed an increase of Adipsin, MIP-1b, and IL-6, associated with a decrease of IL-8 thresholds, related with ALS patients. This biomarker panel analysis could represent an important aid for diagnosis of ALS alongside the clinical and neurophysiological criteria.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199888PMC
http://dx.doi.org/10.1155/2018/3023826DOI Listing

Publication Analysis

Top Keywords

adipsin mip-1b
8
als patients
8
als
6
diagnosis
5
mip-1b il-8
4
il-8 csf
4
csf biomarker
4
biomarker panels
4
panels als
4
als diagnosis
4

Similar Publications

Adipsin, MIP-1b, and IL-8 as CSF Biomarker Panels for ALS Diagnosis.

Dis Markers

February 2019

Tecnologico de Monterrey, Ave. Morones Prieto 3000, Escuela de Medicina y Ciencias de la Salud, Monterrey, NL, 64710, Mexico.

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that selectively attacks motor neurons in the brain and spinal cord. Despite important advances in the knowledge of the etiology and progression of the disease, there are still no solid grounds in which a clinician could make an early objective and reliable diagnosis from which patients could benefit. Diagnosis is difficult and basically made by clinical rating scales (ALSRs and El Escorial).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!