AI Article Synopsis
- The study examined the expression of micro ribonucleic acids (miR-24 and miR-101) in advanced gastric cancer tissues compared to normal tissues from patients.
- The research involved 247 gastric cancer samples and found that miR-24 levels were significantly higher in cancer tissues, while miR-101 levels were lower, with both showing correlations to tumor characteristics like differentiation and metastasis.
- Additionally, miR-24 and miR-101 were identified as independent prognostic factors for overall survival, suggesting their potential role in cancer progression and as indicators for patient prognosis.
Article Abstract
Clinical significance of micro ribonucleic acid (miR)-24 and miR-101 were investigated by evaluating the expression of miR-24 and miR-101 in the tissues of patients with advanced gastric cancer. A total of 247 gastric cancer tissue specimens and 150 cancer-adjacent normal tissues (>5 cm away from the tumor) from patients with advanced gastric cancer who underwent surgical resection in the Surgical Oncology Department of Tianjin Union Medical Centre (Tianjin, China) from April 2013 to May 2016 were collected. The expression of miR-24 and miR-101 in gastric cancer and cancer-adjacent normal tissues were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the correlation of the levels of miR-24 and miR-101 in gastric cancer tissues with their clinical and pathological features were explored. The expression level of miR-24 in gastric cancer tissues was significantly higher than that in cancer-adjacent normal tissues (t=10.26, p<0.01), while the expression level of miR-101 was significantly lower (t=13.940, p<0.01). The expression of miR-24 and miR-101 in gastric cancer was correlated with the pathological differentiation degree of the tumor, lymph node metastasis and depth of infiltration (p<0.05). The multivariate Cox regression analysis revealed that miR-24 and miR-101 were independent prognostic factors affecting the overall survival of patients (p<0.01). The results indicated that the expression of miR-24 is upregulated and that of miR-101 is downregulated in gastric cancer tissues. miR-24 and miR-101 may promote the occurrence, development, infiltration and metastasis of gastric cancer, and can be indicators for the prognosis of patients with gastric cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202543 | PMC |
| http://dx.doi.org/10.3892/ol.2018.9324 | DOI Listing |
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