AI Article Synopsis
- A novel agent for controlling schistosomiasis was developed through examining the anti-schistosomal properties of aerial plant extracts, leading to the identification of three active compounds.
- The effectiveness of the ethanol extract (EE) and the primary compound (CI) was tested against various life stages of the schistosoma parasite, showing significant anti-parasitic effects depending on the concentration and incubation time.
- Results revealed that both EE and CI caused observable damage to schistosoma structure through scanning electron microscopy (SEM), with EE showing moderate cytotoxicity.
Article Abstract
Development of a novel agent for control of schistosomiasis is a mandate. anti-schistosomal activity of the aerial parts of were examined. Chromatographic investigations of the ethanol extract (EE) were afforded three compounds. Pregnane glycoside (CI) 12--hydroxy-benzoyl-20-acetyl-boucerin-3--D-glucopyranosyl-(1→4)--D-cymaropyranosyl-(1→4)-D-cymaropyranoside, in addition to two flavonoids (CII) luteolin-4'---D-neohesperidoside and (CIII)quercetin-3-rutinoside were recognized spectral analysis. The schistosomicidal effects were evaluated using scanning electron microscope (SEM). bioassays on the viability (mobility, morphological changes and mortality) of adults, cercariae, miracidia and eggs at different concentrations 2.5, 5, 12.5, 25 and 50 μg/ml of EE and 2.6, 5.2, 13, 26 and 52 μM of CI in incubation times 1,2,4,6,12hrs were carried out. EE and CI evidenced anti-schistosomal activity with a dose and incubation time-dependent fashion. The effect of EE and CI was evident by the topography damage showed by SEM. EE proved moderate cytotoxicity with IC of 8.48 µg/ml.
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| http://dx.doi.org/10.1080/14786419.2018.1528584 | DOI Listing |
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