Tofacitinib for the Treatment of Pyoderma Gangrenosum.

Clin Gastroenterol Hepatol

Multidisciplinary Center for Inflammatory Bowel Disease, University of North Carolina, Chapel Hill, North Carolina; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

Published: April 2019

Pyoderma gangrenosum (PG) is a difficult-to-treat inflammatory skin condition that affects inflammatory bowel disease (IBD) patients. There is no standardized approach for PG treatment. We report the results of 3 patients with Crohn's disease (CD) and refractory PG who had failed several therapies with biologics and were started on tofacitinib for severe inflammatory arthritis with resolution of their PG.

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http://dx.doi.org/10.1016/j.cgh.2018.10.047DOI Listing

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