In this issue of Structure, Zheng et al. (2018) have described the dynamics of PPARγ in complex with a non-agonist by exploring its solution-phase conformational landscape through chemical cross-linking in combination with a multitude of different treatment conditions, including their new synthetic anti-diabetic non-agonist, revealing the physical mechanism of PPARγ inactivation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516750 | PMC |
| http://dx.doi.org/10.1016/j.str.2018.10.015 | DOI Listing |
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