AI Article Synopsis
- Retinal dopamine plays a crucial role in regulating sharp vision and the connectivity of photoreceptors in the retina.
- Dopaminergic amacrine cells (DACs) are the only source of retinal dopamine, with their release being influenced by light and following a circadian cycle.
- Research shows that while light impacts DAC numbers and dopamine levels, this does not depend on intrinsically photosensitive retinal ganglion cells (ipRGCs), but rather on the rod pathway.
Article Abstract
Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a circadian rhythm and is modulated by light exposure. However, the retinal circuits through which light influences the development and function of DACs are still unknown. Intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged as a prime target for influencing retinal dopamine levels because they costratify with DACs in the inner plexiform layer and signal to them in a retrograde manner. Surprisingly, using genetic mouse models lacking specific phototransduction pathways, we find that while light influences the total number of DACs and retinal dopamine levels, this effect does not require ipRGCs. Instead, we find that the rod pathway is a critical modulator of both DAC number and retinal dopamine levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221543 | PMC |
| http://dx.doi.org/10.7554/eLife.39866 | DOI Listing |
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