In this article, we propose a thermally responsive shape-memory polymer (SMP) consisting of poly(ethylene carbonate) and non-deteriorated lignin nanoparticles. This SMP was obtained readily by thermal kneading and melt molding without requiring any chemical reaction. The shape-recovering properties of the SMP can be tuned by changing the feed ratio of the components. The estimation of viscoelastic, thermal and mechanical properties of the SMP reveals that the stepwise structural transitions in the SMP rendered a dynamic shape-recovering behavior.
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http://dx.doi.org/10.1039/c8sm01683f | DOI Listing |
Biomater Adv
October 2024
Department of Pharmacy, Birla Institute of Technology and Science (BITS PILANI), Pilani, Rajasthan 333031, India. Electronic address:
In the present era of "Diabetic Pandemic", peptide-based therapies have generated immense interest however, are facing odds due to inevitable limitations like stability, delivery complications and off-target effects. One such promising molecule is C-peptide (CPep, 31 amino acid polypeptide with t 30 min); it is a cleaved subunit of pro-insulin, well known to suppress microvascular complications in kidney but has not been able to undergo translation to the clinic till date. Herein, a polymeric CPep nano-complexes (NPX) was prepared by leveraging electrostatic interaction between in-house synthesized cationic, polyethylene carbonate (PEC) based copolymer (Mol.
View Article and Find Full Text PDFPhys Chem Chem Phys
February 2023
Helmholtz Institute Münster, IEK-12, Forschungszentrum Jülich GmbH, Corrensstraße 46, 48149 Münster, Germany.
Linear poly(alkylene carbonates) such as polyethylene carbonate (PEC) and polypropylene carbonate (PPC) have gained increasing interest due to their remarkable ion transport properties such as high Li transference numbers. The cause of these properties is not yet fully understood which makes it challenging to replicate them in other polymer electrolytes. Therefore, it is critical to understand the underlying mechanisms in polycarbonate electrolytes such as PPC.
View Article and Find Full Text PDFJ Pharm Pharmacol
August 2018
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Objective: Pulmonary delivery of antibiotics will decrease the required dose for efficient treatment of lung infections and reduce systemic side effects of the drug. The objective was to evaluate the applicability of poly(ethylene carbonate) (PEC) for the preparation of inhalable, antibiotic-containing particles.
Methods: Rifampicin (RF)-loaded microparticles were prepared by electrospraying a carrier matrix of polylactic acid (PLA) with 0%, 5% and 10% PEC.
Mater Sci Eng C Mater Biol Appl
August 2018
College of Chemistry & Pharmacy, Qingdao Agricultural University, Qingdao 266109, China. Electronic address:
A novel amphiphilic block polymer poly(ethylene glycol)-poly(propylene carbonate)-poly(ethylene glycol) (PEG-PPC-PEG) was synthesized via the dicyclohexylcarbodiimide condensation reaction of double PEG-bis-amine and HOOC-PPC-COOH. The obtained copolymer was characterized by NMR to determine its structure. Using the PEG-PPC-PEG as the carrier and using doxorubicin (DOX) as a model drug, DOX-loaded nanoparticles with core shell structure were synthesized by self-assembly in water.
View Article and Find Full Text PDFMacromol Rapid Commun
July 2018
Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Electrolytes comprising poly(ethylene carbonate) (PEC)/poly(trimethylene carbonate) (PTM C) with lithium bis(trifluoromethane sulfonyl)imide (LiTFSI) are prepared by a simple solvent casting method. Although PEC and PTMC have similar chemical structures, they are immiscible and two glass transitions are present in the differential scanning calorimetry (DSC) measurements. Interestingly, these two polymers change to miscible blends with the addition of LiTFSI, and the ionic conductivity increases with increasing lithium salt concentration.
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