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Ginseng ( Meyer) Oligopeptides Protect Against Binge Drinking-Induced Liver Damage through Inhibiting Oxidative Stress and Inflammation in Rats. | LitMetric

AI Article Synopsis

  • C.A. Meyer (ginseng) is a traditional herb known for its medicinal properties, but research has focused more on ginsenosides and polysaccharides than on its small molecule oligopeptides (GOPs).
  • A study was conducted to explore how GOPs affect alcohol-induced liver damage in rats, where various groups were given different doses of GOPs for 30 days before being administered ethanol.
  • The results showed that GOPs significantly improved liver enzyme levels, inflammation markers, and oxidative stress indicators, suggesting that GOPs help protect the liver from binge drinking injury through inhibition of specific signaling pathways.

Article Abstract

C.A. Meyer (ginseng) is an edible and traditional medicinal herb, which is reported to have a wide range of biological activity and pharmaceutical properties. There were more studies on ginsenoside and polysaccharides, but fewer on ginseng oligopeptides (GOPs), which are small molecule oligopeptides extracted from ginseng. The present study was designed to investigate the effects and underlying mechanism of ginseng oligopeptide (GOPs) on binge drinking-induced alcohol damage in rats. Sprague Dawley rats were randomly assigned to six groups ( = 10), rats in normal control group and alcohol model group was administered distilled water; rats in four GOPs intervention groups (at a dose of 0.0625, 0.125, 0.25, 0.5 g/kg of body weight, respectively) were administered GOPs once a day for 30 days. Experiment rats were intragastrically administered ethanol at a one-time dose of 7 g/kg of body weight after 30 days. The liver injury was measured through traditional liver enzymes, inflammatory cytokines, expression of oxidative stress markers, and histopathological examination. We found that the GOPs treatment could significantly improve serum alanine aminotransferase and aspartate aminotransferase, plasma lipopolysaccharide, and inflammatory cytokine levels, as well as the oxidative stress markers that were altered by alcohol. Moreover, GOPs treatment inhibited the protein expression of toll-like receptor 4, and repressed the inhibitor kappa Bα and nuclear factor-κB p65 in the liver. These findings suggested that GOPs have a significant protective effect on binge drinking-induced liver injury, and the mechanism possibly mediated by the partial inhibition of lipopolysaccharide-toll-like receptor 4-nuclear factor-κB p65 signaling in the liver.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266439PMC
http://dx.doi.org/10.3390/nu10111665DOI Listing

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