Antinuclear antibody (ANA) in chickens infected with reovirus was first detected at 3 weeks postinfection (PI). The antibody titer was greatest at 10 weeks PI (1:2560) and then declined. From 19 to 30 weeks PI, the birds were negative for ANA. The ANA was of both IgG and IgM types. The association between antinuclear factor and reoviral arthritis is discussed.

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