Three cyclonerane sesquiterpenoids, including the known cyclonerodiol (), together with its new derivatives, (10)-12-acetoxy-10-cycloneren-3,7 -diol () and 12-acetoxycycloneran-3,7-diol () were isolated from the cultures of marine-sediment-derived fungus P1-4. The structures of the new compounds ( and ) were elucidated based on extensive spectroscopic methods (1D/2D NMR and HR-MS) and optical rotation analysis.
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http://dx.doi.org/10.1080/14786419.2018.1522314 | DOI Listing |
Molecules
December 2024
College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
Org Lett
January 2025
Key Laboratory of Chemical Biology (Ministry of Education), Shandong Basic Science Research Center (Pharmacy), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China.
Metabolic blockade-based genome mining of the marine sediment-derived SCSIO 07745 led to the discovery of 11 novel aminoquinolinone alkaloids, oxazoquinolinones A-J (-), characterized by an oxazolidone[3,2-α]quinoline-5,8-dione scaffold, and oxazoquinolinone K (), featuring an unprecedented fused 6/6/6/5 tetracyclic core ring system. Additionally, 5 new biosynthetic intermediates or shunt products (-) and a known metabolite sannanine () were identified. Their structures were elucidated by extensive spectroscopic analyses and a comparison of electronic circular dichroism and single-crystal X-ray diffraction.
View Article and Find Full Text PDFMicrob Cell Fact
October 2024
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.
Mar Drugs
January 2024
GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Product Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Wischhofstrasse 1-3, 24148 Kiel, Germany.
Co-cultivation, coupled with the OSMAC approach, is considered an efficient method for expanding microbial chemical diversity through the activation of cryptic biosynthetic gene clusters (BGCs). As part of our project aiming to discover new fungal metabolites for crop protection, we previously reported five polyketides, the macrolides dendrodolides E () and N (), the azaphilones spiciferinone () and 8-hydroxy-spiciferinone (), and the -naphtho--pyrone cephalochromin () from the solid Potato Dextrose Agar (PDA) co-culture of two marine sediment-derived fungi, and . However, some of the purified metabolites could not be tested due to their minute quantities.
View Article and Find Full Text PDFMar Drugs
December 2023
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
A new prenylated indole diketopiperazine alkaloid, rubrumline P (), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, , collected at a depth of 15 m near the lighthouse in Dahab, Red Sea, Egypt. In the current study, a bioassay-guided fractionation allowed for the identification of an active fraction displaying significant cytotoxic activity against the human pancreatic adenocarcinoma cell line PANC-1 from the EtOAc extract of the investigated fungus compared to the standard paclitaxel. The structures of the isolated compounds from the active fraction were established using 1D/2D NMR spectroscopy and mass spectrometry, together with comparisons with the literature.
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