Large-scale individual thyroid monitoring following nuclear accidents by means of non-spectrometric devices.

J Radiol Prot

Radiation Protection Institute, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Via Anguillarese 301, I-00123 Casaccia-Rome, Italy.

Published: December 2018

In order to properly respond to an emergency caused by an accident in a nuclear power plant with a spread of radionuclides in the atmosphere, we propose a field procedure to perform a large-scale individual thyroid monitoring of internal contamination due to inhalation of I, by means of non-spectrometric equipment, in particular dose rate meters. Specific attention is paid to the individual monitoring of children, because of the very high radiosensitivity of the child's thyroid to the carcinogenic effects of ionising radiation. The device performance was evaluated by measuring mock iodine sources provided in the Child and Adult Thyroid Monitoring After Reactor Accident (CAThyMARA) intercomparison and, just for a scintillator dose rate meter, by means of 60 s acquisitions of healthy volunteers' thyroids. All the devices showed a remarkable accuracy in quantification of equivalent I activity in the thyroids of persons of all ages. The selected scintillator dose rate meter showed detection limit values resulting in a maximum committed equivalent dose to thyroid H, assuming an acute I inhalation occurred five days before the measurement, equal to 10 mSv (related to five-year-old children). Considering the level of H values associated with the calculated detection limit activities, the proposed procedure has a significant sensitivity to be used for fast internally thyroid monitoring in nuclear or radiological emergencies, allowing daily monitoring a large amount of individuals.

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6498/aae85eDOI Listing

Publication Analysis

Top Keywords

thyroid monitoring
16
dose rate
12
large-scale individual
8
individual thyroid
8
monitoring nuclear
8
scintillator dose
8
rate meter
8
detection limit
8
thyroid
6
monitoring
6

Similar Publications

Langerhans cell histiocytosis in children: the value of ultrasound in diagnosis and follow-up.

BMC Med Imaging

January 2025

Department of Ultrasound Medicine, First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.

Background: Langerhans cell histiocytosis (LCH) is a rare disease, most prevalent in children. Ultrasound is a noninvasive, cheap, and widely available technique. However, systematic elucidation of sonographic features of LCH and treatment related follow-up are relatively few, resulting in overall underestimation of the clinical value of ultrasound in diagnosing and monitoring LCH.

View Article and Find Full Text PDF

This case highlights that refractory pancytopenia leading to death can occur with methimazole treatment even at a very low cumulative dose and after a very short duration of exposure. In addition, the standard treatments to correct the pancytopenia may not be effective and a bone marrow transplant may be required. Current American Thyroid Association guidelines do not recommend routine monitoring of the complete blood count in patients receiving thionamides because of the rapidity of the onset of agranulocytosis and the lack of positive evidence that such monitoring would be useful.

View Article and Find Full Text PDF

Molecular mechanism of long chain non coding RNA LINC00511 influencing breast cancer stem cells: Mechanism of VEGFR1 protein.

Int J Biol Macromol

January 2025

Department of Hepatobiliary Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, PR China; Department of Breast and Thyroid Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, PR China; Key Laloratory of Molecular Pathology in Tumors of Guangxi, Baise 533000, Guangxi, PR China; Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17176, Sweden. Electronic address:

A comprehensive investigation into the mechanism of VEGFR1 protein in this process was undertaken. Lentivirus-mediated RNA interference was employed to inhibit the expression of LINC00511 in breast cancer cell lines, and changes in breast cancer stem cell markers, including CD44+/CD24-, were monitored using flow cytometry. Additionally, the interaction between VEGFR1 protein and LINC00511 and the activation of its downstream signaling pathway were investigated through co-immunoprecipitation (Co-IP) and Western blot techniques.

View Article and Find Full Text PDF

Background: Thyroid nodules classified cytologically as low-risk indeterminate lesions (TIR3A) on fine-needle aspiration biopsy (FNAB) present a clinical challenge due to their uncertain malignancy risk. This single-center study aimed to evaluate the natural history of TIR3A nodules.

Materials And Methods: FNABs performed between July 2017 and December 2019 were retrospectively retrieved and patients with TIR3A nodules were evaluated at baseline and throughout a follow-up based on ultrasound (US) parameters and clinical data.

View Article and Find Full Text PDF
Article Synopsis
  • Intraoperative neuromonitoring (IONM) is valuable in thyroid/parathyroid surgeries and aims to assess vocal cord paralysis (VCP) through variations in recurrent laryngeal nerve (RLN) amplitudes.
  • A study involving 728 RLNs found that specific amplitude ranges (particularly V2 at 117-216 μV) effectively predicted VCP with high sensitivity and specificity.
  • The findings suggest that measuring V2 amplitudes can serve as a reliable method to predict postoperative VCP, especially when initial vagus nerve exposure is limited.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!